Hormones and antioxidant systems: role of pituitary and pituitary-dependent axes.

Antonio Mancini, Andrea Silvestrini, Elisabetta Meucci, Alfredo Pontecorvi, Vincenzo Di Donna, Erika Leone, Roberto Festa, Gian Paolo Littarru

Risultato della ricerca: Contributo in rivistaArticolo in rivista

30 Citazioni (Scopus)

Abstract

Oxidative stress, a condition defined as unbalancing between production of free radicals and antioxidant defenses, is an important pathogenetic mechanism in different diseases. Despite the abundant literature, many aspects of hormone role in regulating antioxidant synthesis and activity still remain obscure. Therefore, we reviewed experimental data, in vivo and in vitro, about the effects of the different pituitary- dependent axes on antioxidant levels, trying to give a broad view from hormones which also have antioxidant properties to the classic antioxidants, from the lipophilic antioxidant Coenzyme Q10, strictly related to thyroid function, to total antioxidant capacity, a measure of non-protein non-enzymatic antioxidants in serum and other biological fluids. Taken together, these data underline the importance of oxidative stress in various pituitary-dependent disorders, suggesting a possible clinical usefulness of antioxidant molecules.
Lingua originaleEnglish
pagine (da-a)422-433
Numero di pagine12
RivistaJournal of Endocrinological Investigation
Volume2010
Stato di pubblicazionePubblicato - 2010

Keywords

  • antioxidants
  • pituitary
  • thyroid

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