Hormonal and metabolic evaluation in Down's syndrome: preliminary evidence for TSH dysregulation in hyperthyrotropinemic patients

In conclusion DS could represent another condition in which the evaluation of metabolic indexes, such as CoQ10 and SHBG, could fournish reliable indications on the metabolic status of the patients, since basal TSH values, even when clearly altered, do not allow to focus a hypothyroidism when considered alone. These considerations should be kept in mind when a thyroid dysfunction is suspected in DS, and the metabolic assessment should be carefully evaluated before starting a thyroid replacement therapy in such a condition