Hormonal and metabolic evaluation in Down's syndrome: preliminary evidence for TSH dysregulation in hyperthyrotropinemic patients

Antonio Mancini; Paolo Mariotti; Gianluigi Conte; Domenico Milardi; Antonio Bianchi; Alessandra Fusco; Laura De Marinis Grasso; Ml Fabrizi; A Panichelli; Gp Littarru

doi:10.1055/s-2005-873016

Hormonal and metabolic evaluation in Down's syndrome: preliminary evidence for TSH dysregulation in hyperthyrotropinemic patients

Antonio Mancini, Paolo Mariotti, Gianluigi Conte, Domenico Milardi, Antonio Bianchi, Alessandra Fusco, Laura De Marinis Grasso, Ml Fabrizi, A Panichelli, Gp Littarru

Risultato della ricerca: Contributo in rivista › Articolo in rivista

2 Citazioni (Scopus)

Abstract

In conclusion DS could represent another condition in which the evaluation of metabolic indexes, such as CoQ10 and SHBG, could fournish reliable indications on the metabolic status of the patients, since basal TSH values, even when clearly altered, do not allow to focus a hypothyroidism when considered alone. These considerations should be kept in mind when a thyroid dysfunction is suspected in DS, and the metabolic assessment should be carefully evaluated before starting a thyroid replacement therapy in such a condition

Lingua originale	English
pagine (da-a)	39-40
Numero di pagine	2
Rivista	EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
Volume	114
DOI	https://doi.org/10.1055/s-2005-873016
Stato di pubblicazione	Pubblicato - 2006

Keywords

Adolescent
Adult
Coenzymes
Down Syndrome
Female
Humans
Male
Thyroid Diseases
Thyroid Hormones
Thyrotropin
Thyrotropin-Releasing Hormone
Ubiquinone

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10.1055/s-2005-873016

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Mancini, A., Mariotti, P., Conte, G., Milardi, D., Bianchi, A., Fusco, A., De Marinis Grasso, L., Fabrizi, M., Panichelli, A., & Littarru, G. (2006). Hormonal and metabolic evaluation in Down's syndrome: preliminary evidence for TSH dysregulation in hyperthyrotropinemic patients. EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 114, 39-40. https://doi.org/10.1055/s-2005-873016

Mancini, Antonio ; Mariotti, Paolo ; Conte, Gianluigi ; Milardi, Domenico ; Bianchi, Antonio ; Fusco, Alessandra ; De Marinis Grasso, Laura ; Fabrizi, Ml ; Panichelli, A ; Littarru, Gp. / Hormonal and metabolic evaluation in Down's syndrome: preliminary evidence for TSH dysregulation in hyperthyrotropinemic patients. In: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES. 2006 ; Vol. 114. pagg. 39-40.

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title = "Hormonal and metabolic evaluation in Down's syndrome: preliminary evidence for TSH dysregulation in hyperthyrotropinemic patients",

abstract = "In conclusion DS could represent another condition in which the evaluation of metabolic indexes, such as CoQ10 and SHBG, could fournish reliable indications on the metabolic status of the patients, since basal TSH values, even when clearly altered, do not allow to focus a hypothyroidism when considered alone. These considerations should be kept in mind when a thyroid dysfunction is suspected in DS, and the metabolic assessment should be carefully evaluated before starting a thyroid replacement therapy in such a condition",

keywords = "Adolescent, Adult, Coenzymes, Down Syndrome, Female, Humans, Male, Thyroid Diseases, Thyroid Hormones, Thyrotropin, Thyrotropin-Releasing Hormone, Ubiquinone, Adolescent, Adult, Coenzymes, Down Syndrome, Female, Humans, Male, Thyroid Diseases, Thyroid Hormones, Thyrotropin, Thyrotropin-Releasing Hormone, Ubiquinone",

author = "Antonio Mancini and Paolo Mariotti and Gianluigi Conte and Domenico Milardi and Antonio Bianchi and Alessandra Fusco and {De Marinis Grasso}, Laura and Ml Fabrizi and A Panichelli and Gp Littarru",

year = "2006",

doi = "10.1055/s-2005-873016",

language = "English",

volume = "114",

pages = "39--40",

journal = "Experimental and Clinical Endocrinology and Diabetes",

issn = "0947-7349",

publisher = "MVS Medizinverlage Stuttgart:Postfach 301120, D 70451 Stuttgart Germany:011 49 711 8931321, EMAIL: aboservice@thieme.de, Fax: 011 49 711 8931422 Stuttgart; New York: Barth in Georg-Thieme-Verl..",

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Mancini, A, Mariotti, P, Conte, G, Milardi, D, Bianchi, A, Fusco, A, De Marinis Grasso, L, Fabrizi, M, Panichelli, A & Littarru, G 2006, 'Hormonal and metabolic evaluation in Down's syndrome: preliminary evidence for TSH dysregulation in hyperthyrotropinemic patients', EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, vol. 114, pagg. 39-40. https://doi.org/10.1055/s-2005-873016

Hormonal and metabolic evaluation in Down's syndrome: preliminary evidence for TSH dysregulation in hyperthyrotropinemic patients. / Mancini, Antonio; Mariotti, Paolo; Conte, Gianluigi; Milardi, Domenico; Bianchi, Antonio; Fusco, Alessandra; De Marinis Grasso, Laura; Fabrizi, Ml; Panichelli, A; Littarru, Gp.

In: EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, Vol. 114, 2006, pag. 39-40.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - Hormonal and metabolic evaluation in Down's syndrome: preliminary evidence for TSH dysregulation in hyperthyrotropinemic patients

AU - Mancini, Antonio

AU - Mariotti, Paolo

AU - Conte, Gianluigi

AU - Milardi, Domenico

AU - Bianchi, Antonio

AU - Fusco, Alessandra

AU - De Marinis Grasso, Laura

AU - Fabrizi, Ml

AU - Panichelli, A

AU - Littarru, Gp

PY - 2006

Y1 - 2006

N2 - In conclusion DS could represent another condition in which the evaluation of metabolic indexes, such as CoQ10 and SHBG, could fournish reliable indications on the metabolic status of the patients, since basal TSH values, even when clearly altered, do not allow to focus a hypothyroidism when considered alone. These considerations should be kept in mind when a thyroid dysfunction is suspected in DS, and the metabolic assessment should be carefully evaluated before starting a thyroid replacement therapy in such a condition

AB - In conclusion DS could represent another condition in which the evaluation of metabolic indexes, such as CoQ10 and SHBG, could fournish reliable indications on the metabolic status of the patients, since basal TSH values, even when clearly altered, do not allow to focus a hypothyroidism when considered alone. These considerations should be kept in mind when a thyroid dysfunction is suspected in DS, and the metabolic assessment should be carefully evaluated before starting a thyroid replacement therapy in such a condition

KW - Adolescent

KW - Adult

KW - Coenzymes

KW - Down Syndrome

KW - Female

KW - Humans

KW - Male

KW - Thyroid Diseases

KW - Thyroid Hormones

KW - Thyrotropin

KW - Thyrotropin-Releasing Hormone

KW - Ubiquinone

KW - Adolescent

KW - Adult

KW - Coenzymes

KW - Down Syndrome

KW - Female

KW - Humans

KW - Male

KW - Thyroid Diseases

KW - Thyroid Hormones

KW - Thyrotropin

KW - Thyrotropin-Releasing Hormone

KW - Ubiquinone

UR - http://hdl.handle.net/10807/21056

U2 - 10.1055/s-2005-873016

DO - 10.1055/s-2005-873016

M3 - Article

VL - 114

SP - 39

EP - 40

JO - Experimental and Clinical Endocrinology and Diabetes

JF - Experimental and Clinical Endocrinology and Diabetes

SN - 0947-7349

ER -

Hormonal and metabolic evaluation in Down's syndrome: preliminary evidence for TSH dysregulation in hyperthyrotropinemic patients

Abstract

Keywords

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