TY - JOUR
T1 - Hopelessness, Dissociative Symptoms, and Suicide Risk in Major Depressive Disorder: Clinical and Biological Correlates
AU - Pettorruso, Mauro
AU - D’Andrea, Giacomo
AU - Martinotti, Giovanni
AU - Cocciolillo, Fabrizio
AU - Miuli, Andrea
AU - Di Muzio, Ilenia
AU - Collevecchio, Rebecca
AU - Verrastro, Valeria
AU - De Giorgio, Fabio
AU - Janiri, Luigi
AU - Di Giannantonio, Massimo
AU - Di Giuda, Daniela
AU - Camardese, Giovanni
PY - 2020
Y1 - 2020
N2 - Background:Major depressive disorder (MDD) has different clinical presentations and is associated with neurobiological alterations. Hopelessness, anhedonia, and dissociation represent some of the most pervasive psychopathological symptoms that often lead to suicidal thoughts, attempts, and actions. To further research on the concept of depression endophenotypes, this study aimed to assess the possible relationships between hopelessness and other clinical and biological correlates (i.e., striatal dopaminergic dysfunction) in depressed patients.Methods:We recruited 51 subjects with MDD. All subjects underwent(123)I-FP-CIT SPECT to assess striatal dopamine transporter (DAT) availability and a psychometric evaluation using the psychometric scale to assess depressive, anxious, dissociative, and hopelessness symptoms aside from suicidal ideation.Result:An inverse correlation between the hopelessness score and dopamine transporter availability in all basal ganglia was bilaterally found. (Right Putamen,r= -0.445,p< 0.01; Left Putamen,r= -0.454,p< 0.01; Right Caudate,r= -0.398,p< 0.01; Left Caudate,r= -0.467,p< 0.01) Moreover, a positive correlation was also found between hopelessness and dissociative symptoms.Conclusions:These results provide important evidence on the neurobiological and clinical correlates of different psychopathological symptoms of depression with potential implications in terms of devising more effective treatment programs.
AB - Background:Major depressive disorder (MDD) has different clinical presentations and is associated with neurobiological alterations. Hopelessness, anhedonia, and dissociation represent some of the most pervasive psychopathological symptoms that often lead to suicidal thoughts, attempts, and actions. To further research on the concept of depression endophenotypes, this study aimed to assess the possible relationships between hopelessness and other clinical and biological correlates (i.e., striatal dopaminergic dysfunction) in depressed patients.Methods:We recruited 51 subjects with MDD. All subjects underwent(123)I-FP-CIT SPECT to assess striatal dopamine transporter (DAT) availability and a psychometric evaluation using the psychometric scale to assess depressive, anxious, dissociative, and hopelessness symptoms aside from suicidal ideation.Result:An inverse correlation between the hopelessness score and dopamine transporter availability in all basal ganglia was bilaterally found. (Right Putamen,r= -0.445,p< 0.01; Left Putamen,r= -0.454,p< 0.01; Right Caudate,r= -0.398,p< 0.01; Left Caudate,r= -0.467,p< 0.01) Moreover, a positive correlation was also found between hopelessness and dissociative symptoms.Conclusions:These results provide important evidence on the neurobiological and clinical correlates of different psychopathological symptoms of depression with potential implications in terms of devising more effective treatment programs.
KW - Dopamine Transporter, suicidality, mood disorders, DaTSCAN
KW - basal ganglia
KW - dissociation
KW - dopamine transporter
KW - mood disorders
KW - suicidality
KW - Dopamine Transporter, suicidality, mood disorders, DaTSCAN
KW - basal ganglia
KW - dissociation
KW - dopamine transporter
KW - mood disorders
KW - suicidality
UR - http://hdl.handle.net/10807/222084
U2 - 10.3390/brainsci10080519
DO - 10.3390/brainsci10080519
M3 - Article
SN - 2076-3425
VL - 10
SP - 1
EP - 11
JO - Brain Sciences
JF - Brain Sciences
ER -