TY - JOUR
T1 - Homozygosity for human leucocyte antigen-C ligands of KIR2DL1 is associated with increased risk of relapse after human leucocyte antigen-C-matched unrelated donor haematopoietic stem cell transplantation
AU - Giebel, Sebastian
AU - Locatelli, Franco
AU - Wojnar, Jerzy
AU - Velardi, Andrea
AU - Mina, Tommaso
AU - Giorgiani, Giovanna
AU - Krawczyk-Kulis, Malgorzata
AU - Markiewicz, Miroslaw
AU - Wylezol, Iwona
AU - Holowiecki, Jerzy
PY - 2005
Y1 - 2005
N2 - Human leucocyte antigen (HLA)-C molecules regulate the function of natural killer cells and may be subdivided into two groups, C(1) and C(2), based on their specificity for inhibitory killer immunoglobulin-like receptors. We analysed the impact of the HLA-C genotype on outcome of HLA-C-matched unrelated donor haematopoietic stem cell transplantation (URD-HSCT) recipients. HLA-C(2) homozygous patients (n = 18) had lower probability of overall survival (P = 0.01) and disease-free survival (P = 0.02), resulting from increased relapse rate (P = 0.02) when compared with both HLA-C(1) homozygous (n = 43) and HLA-C(1),C(2) heterozygous (n = 50) subgroups. Patients lacking HLA-C(1) should, therefore, be considered at increased risk of relapse following HLA-C-matched URD-HSCT.
AB - Human leucocyte antigen (HLA)-C molecules regulate the function of natural killer cells and may be subdivided into two groups, C(1) and C(2), based on their specificity for inhibitory killer immunoglobulin-like receptors. We analysed the impact of the HLA-C genotype on outcome of HLA-C-matched unrelated donor haematopoietic stem cell transplantation (URD-HSCT) recipients. HLA-C(2) homozygous patients (n = 18) had lower probability of overall survival (P = 0.01) and disease-free survival (P = 0.02), resulting from increased relapse rate (P = 0.02) when compared with both HLA-C(1) homozygous (n = 43) and HLA-C(1),C(2) heterozygous (n = 50) subgroups. Patients lacking HLA-C(1) should, therefore, be considered at increased risk of relapse following HLA-C-matched URD-HSCT.
KW - human leucocyte antigen-C
KW - killer immunoglobulin-like receptor ligand
KW - relapse
KW - survival
KW - unrelated donor haematopoietic stem cell transplantation
KW - human leucocyte antigen-C
KW - killer immunoglobulin-like receptor ligand
KW - relapse
KW - survival
KW - unrelated donor haematopoietic stem cell transplantation
UR - https://publicatt.unicatt.it/handle/10807/259142
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=33644806244&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33644806244&origin=inward
U2 - 10.1111/j.1365-2141.2005.05797.x
DO - 10.1111/j.1365-2141.2005.05797.x
M3 - Article
SN - 0007-1048
VL - 131
SP - 483
EP - 486
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 147
ER -
