HLA-DR is aberrantly expressed at feto-maternal interface in pre-eclampsia

Giovanni Scambia, Chiara Tersigni, Nicoletta Di Simone, C. W. Redman, R. Dragovic, D. Tannetta, I. Sargent, M. Vatish

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

13 Citazioni (Scopus)

Abstract

In normal pregnancy, villous cytotrophoblast and syncytiotrophoblast do not express HLA Class I and Class II molecules, while invasive extravillous trophoblast only express class I HLA-C and the atypical class Ib antigens, HLA-G, -E and -F. Inadequate maternal tolerance of invasive trophoblast has been proposed as a possible immunologic trigger of poor trophoblast invasion and subsequent occurrence of pre-eclampsia. This study aimed to investigate possible aberrant expression of class II HLA-DR on placentae and syncytiotrophoblast-derived extracellular vesicles (STEVs), obtained by dual placental perfusion, from pre-eclampsia (n = 23) and normal pregnant (n = 14) women. Here we demonstrate that HLA-DR can be detected in syncytiotrophoblast from a significant proportion of pre-eclampsia but not control placentae. HLA-DR was also observed, by flow cytometry, on STEVs and associated with placental alkaline phosphatase to validate their placental origin. HLA-DR positive syncytiotrophoblast was detected in placental biopsies from pre-eclampsia but not normal control cases, using immunohistochemistry. The HLA may be fetal or maternal origin. In the latter case a possible mechanism of acquisition is trogocytosis.
Lingua originaleEnglish
pagine (da-a)48-52
Numero di pagine5
RivistaJournal of Reproductive Immunology
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Extracellular vesicles
  • Feto-maternal interface
  • HLA-DR
  • Pre-eclampsia

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