TY - JOUR
T1 - Hippo pathway and breast cancer stem cells
AU - Maugeri-Saccà, Marcello
AU - De Maria Marchiano, Ruggero
PY - 2016
Y1 - 2016
N2 - Tumors contain a specialized subset of cells with unique properties, such as self-renewal and tumorigenic potential. These cancer stem-like cells (CSCs) are supposed to be responsible for therapeutic resistance and metastatic spread. Functional characterization of breast CSCs (BCSCs) is beginning to shed light on molecular networks which are specifically activated in this cellular compartment, and that account for the retention/acquisition of stem-like features. The Hippo tumor suppressor pathway has increasingly been tied to breast cancer. Altered Hippo activity, or Hippo-independent mechanisms, mediate the activation of the Hippo transducers TAZ and YAP. When this occurs, cancer cells acquire more aggressive traits. In the realm of BCSCs, improper TAZ/YAP activity sustains self-renewal, resistance to conventional anticancer agents, and metastatic dissemination. In this review, we highlight the involvement of TAZ and YAP in mammary gland development and in BCSCs. We also discuss potential strategies for transferring this information into the clinical setting.
AB - Tumors contain a specialized subset of cells with unique properties, such as self-renewal and tumorigenic potential. These cancer stem-like cells (CSCs) are supposed to be responsible for therapeutic resistance and metastatic spread. Functional characterization of breast CSCs (BCSCs) is beginning to shed light on molecular networks which are specifically activated in this cellular compartment, and that account for the retention/acquisition of stem-like features. The Hippo tumor suppressor pathway has increasingly been tied to breast cancer. Altered Hippo activity, or Hippo-independent mechanisms, mediate the activation of the Hippo transducers TAZ and YAP. When this occurs, cancer cells acquire more aggressive traits. In the realm of BCSCs, improper TAZ/YAP activity sustains self-renewal, resistance to conventional anticancer agents, and metastatic dissemination. In this review, we highlight the involvement of TAZ and YAP in mammary gland development and in BCSCs. We also discuss potential strategies for transferring this information into the clinical setting.
KW - Breast Neoplasms
KW - Breast cancer
KW - Cancer stem Cells
KW - Female
KW - Genes, Tumor Suppressor
KW - Geriatrics and Gerontology
KW - Hematology
KW - Hippo pathway
KW - Humans
KW - Neoplastic Stem Cells
KW - Oncology
KW - Protein-Serine-Threonine Kinases
KW - Signal Transduction
KW - Breast Neoplasms
KW - Breast cancer
KW - Cancer stem Cells
KW - Female
KW - Genes, Tumor Suppressor
KW - Geriatrics and Gerontology
KW - Hematology
KW - Hippo pathway
KW - Humans
KW - Neoplastic Stem Cells
KW - Oncology
KW - Protein-Serine-Threonine Kinases
KW - Signal Transduction
UR - http://hdl.handle.net/10807/112007
UR - http://www.elsevier.com/locate/critrevonc
U2 - 10.1016/j.critrevonc.2015.12.004
DO - 10.1016/j.critrevonc.2015.12.004
M3 - Article
SN - 1040-8428
VL - 99
SP - 115
EP - 122
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
ER -