TY - JOUR
T1 - Highly bactericidal Ag nanoparticle films obtained by cluster beam deposition
AU - Cavaliere, Emanuele
AU - De Cesari, Sebastiano
AU - Landini, Giulia
AU - Riccobono, Eleonora
AU - Pallecchi, Lucia
AU - Rossolini, Gian Maria
AU - Gavioli, Luca
PY - 2015
Y1 - 2015
N2 - The recent emergence of bacterial pathogens resistant to most or all available antibiotics is among the major global public health problems. As indirect transmission through contaminated surfaces is a main route of dissemination for most of such pathogens, the implementation of effective antimicrobial surfaces has been advocated as a promising approach for their containment, especially in the hospital settings. However, traditional wet synthesis methods of nanoparticle-based antimicrobial materials leave a number of key points open for metal surfaces: such as adhesion to the surface and nanoparticle coalescence. Here we demonstrate an alternative route, i.e. supersonic cluster beam deposition, to obtain antimicrobial Ag nanoparticle films deposited directly on surfaces. The synthesized films are simple to produce with controlled density and thickness, are stable over time, and are shown to be highly bactericidal against major Gram positive and Gram negative bacterial pathogens, including extensively drug-resistant strains.
AB - The recent emergence of bacterial pathogens resistant to most or all available antibiotics is among the major global public health problems. As indirect transmission through contaminated surfaces is a main route of dissemination for most of such pathogens, the implementation of effective antimicrobial surfaces has been advocated as a promising approach for their containment, especially in the hospital settings. However, traditional wet synthesis methods of nanoparticle-based antimicrobial materials leave a number of key points open for metal surfaces: such as adhesion to the surface and nanoparticle coalescence. Here we demonstrate an alternative route, i.e. supersonic cluster beam deposition, to obtain antimicrobial Ag nanoparticle films deposited directly on surfaces. The synthesized films are simple to produce with controlled density and thickness, are stable over time, and are shown to be highly bactericidal against major Gram positive and Gram negative bacterial pathogens, including extensively drug-resistant strains.
KW - Ag nanoparticle-based antimicrobial films
KW - Atomic force microscopy
KW - Bactericidal activity
KW - Electron spectroscopies
KW - Extensively drug-resistant bacteria
KW - Supersonic cluster beam deposition
KW - Ag nanoparticle-based antimicrobial films
KW - Atomic force microscopy
KW - Bactericidal activity
KW - Electron spectroscopies
KW - Extensively drug-resistant bacteria
KW - Supersonic cluster beam deposition
UR - http://hdl.handle.net/10807/68419
U2 - 10.1016/j.nano.2015.02.023
DO - 10.1016/j.nano.2015.02.023
M3 - Article
SN - 1549-9634
VL - 11
SP - 1417
EP - 1423
JO - NANOMEDICINE
JF - NANOMEDICINE
ER -