Higher biologically effective dose predicts survival in SBRT of pancreatic cancer: A multicentric analysis (PAULA-1)

Francesco Deodato, Francesco Cellini, Gabriella Macchia, Savino Cilla, Alessio Giuseppe Morganti, Alessandra Arcelli, Alessandra Guido, Milly Buwenge, Nicola Simoni, Renzo Mazzarotto, Valerio Scotti, Liliana Belgioia, Giorgio Tolento, Elisa Grassi, Mariacristina Di Marco, Riccardo Casadei, Alessio G. Morganti, Silvia Cammelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Aim: The purpose of the present multicentric study was to review stereotactic body radiotherapy (SBRT) with or without chemotherapy (CHT) experience in locally advanced pancreatic cancer (LAPC). Endpoints were overall survival (OS), local control (LC), and distant metastasis-free survival (DMFS). Several parameters’ impact on these outcomes was assessed. Materials and Methods: Fifty-six patients with LAPC undergoing SBRT+/-CHT were included. SBRT median BEDα/β10Gy was 48.0 Gy (range=28.0-78.7). Survival curves were calculated by Kaplan-Meier method. A Cox regression model was fitted. Results: At a median follow-up of 15.0 months, 2-year OS, LC, DMFS were: 33.8% 55.4%, and 22.9%, respectively. Patients treated with BEDα/β10Gy≥48 Gy showed improved OS (p=0.020) and LC (p=0.024). At multivariate analysis, BEDα/β10Gy≥48 Gy was significantly associated to both higher OS (p=0.042) and LC (p=0.045), while post-SBRT CHT improved DMFS (p=0.003). Conclusion: SBRT proved to be tolerable and effective in LAPC. Moreover, BEDα/β10Gy≥48 Gy was significantly correlated with improved OS and LC.
Lingua originaleEnglish
pagine (da-a)465-472
Numero di pagine8
RivistaAnticancer Research
Stato di pubblicazionePubblicato - 2020


  • Chemotherapy
  • Radiosurgery
  • Pancreatic cancer
  • Stereotactic body radiotherapy
  • Adult
  • Aged
  • Aged, 80 and over
  • Disease-Free Survival
  • Dose-Response Relationship, Radiation
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Neoplasms
  • Survival Analysis
  • Dose effect


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