High prevalence of radiological vertebral fractures in women with prolactin-secreting pituitary adenomas

G Mazziotti, T Mancini, Marilda Mormando, E De Menis, Antonio Bianchi, M Doga, Teresa Porcelli, P. P Vescovi, Laura De Marinis Grasso, A. Giustina

Risultato della ricerca: Contributo in rivistaArticolo in rivista

45 Citazioni (Scopus)


Hyperprolactinemia may cause bone loss but data on fractures are scanty. The aim of this study was to evaluate the prevalence of vertebral fractures in women with prolactin (PRL)-secreting adenoma. In this cross-sectional study, 78 women (median age 45.5 years, range: 20-81) with PRL-secreting pituitary adenoma (66 with microadenoma and 12 with macroadenoma) and 156 control subjects, with normal PRL values and with comparable age to patients with hyperprolactinemia, were evaluated for vertebral fractures by a morphometric approach and for bone mineral density (BMD) by a dual-energy X-ray absorptiometry at lumbar spine. Vertebral fractures were shown in 25 patients with PRL-secreting adenoma (32.6%) and in 20 controls (12.8%, P < 0.001). Fractured patients were significantly older (P < 0.001) and had lower BMD T-score (P < 0.001), longer duration of disease (P < 0.001), higher serum PRL (P = 0.004) and lower serum IGF-I (P < 0.001) values as compared to patients who did not fracture. The prevalence of vertebral fractures was significantly (P < 0.001) higher in post-menopausal women with PRL-secreting adenoma as compared to pre-menopausal patients. Fractures occurred more frequently (P = 0.01) in patients with untreated hyperprolactinemia versus patients treated with cabergoline. Logistic regression analysis demonstrated that duration of disease maintained a significant correlation with vertebral fractures (odds ratio 1.16, C.I. 95% 1.02-1.33) even after correction for age, menopausal status, treatment with cabergoline, BMD, serum IGF-I and serum PRL values. Hyperprolactinemia is associated with high prevalence of radiological vertebral fractures in women with PRL-secreting adenoma. © 2011 Springer Science+Business Media, LLC.
Lingua originaleEnglish
pagine (da-a)299-306
Numero di pagine8
Stato di pubblicazionePubblicato - 2011


  • Adult
  • Aged
  • Aged, 80 and over
  • Bone Density
  • Cross-Sectional Studies
  • Female
  • Humans
  • Lumbar Vertebrae
  • Middle Aged
  • Pituitary Neoplasms
  • Prevalence
  • Prolactinoma
  • Spinal Fractures
  • Young Adult
  • aged
  • article
  • bone density
  • cabergoline
  • controlled study
  • cross-sectional study
  • disease association
  • disease duration
  • dual energy X ray absorptiometry
  • female
  • human
  • hyperprolactinemia
  • lumbar spine
  • major clinical study
  • microadenoma
  • morphometrics
  • postmenopause
  • premenopause
  • prevalence
  • priority journal
  • prolactin
  • prolactin blood level
  • prolactinoma
  • protein blood level
  • somatomedin C, adult
  • spine radiography
  • vertebra fracture, Absorptiometry, Photon


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