High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments.

Antonio Gasbarrini; Giovanni Addolorato; Antonio Mirijello; Fabio Lugoboni; Lorenzo Zamboni; Marco Faccini; Rebecca Casari; Anthony Cossari; C. Arzillo; N. Bersani; P. Bersani; C. Biasin; C. Bossi; A. Bottazzo; A. Bove; F. Cantanchin; D. Cantiero; G. Canzian; D. Cargnelutti; M. Cibin; L. De Cecco; E. Dellantonio; F. Dersini; M. Fadelli; E. Favero; N. Fontana; A. Franceschini; M. Gaiga; M. Gardiolo; N. Gentile; N. Ghezzo; M. A. Giacomin; E. Manzato; M. Mazzo; D. Meneghello; C. Mihalcea; E. Milan; M. Montresor; A. Pani; V. Pavani; C. Resentera; M. Residori; P. Righetti; M. A. Ripoli; P. Riscica; C. Rizza; V. Rizzetto; A. Rossi; A. Rovea; A. Ruffato; C. Ruzziconi; N. Sembianti; C. Smacchia; C. Stimolo; E. Zerbetto; M. Zerman

High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments.

Antonio Gasbarrini, Giovanni Addolorato, Antonio Mirijello, Fabio Lugoboni, Lorenzo Zamboni, Marco Faccini, Rebecca Casari, Anthony Cossari, C. Arzillo, N. Bersani, P. Bersani, C. Biasin, C. Bossi, A. Bottazzo, A. Bove, F. Cantanchin, D. Cantiero, G. Canzian, D. Cargnelutti, M. CibinL. De Cecco, E. Dellantonio, F. Dersini, M. Fadelli, E. Favero, N. Fontana, A. Franceschini, M. Gaiga, M. Gardiolo, N. Gentile, N. Ghezzo, M. A. Giacomin, E. Manzato, M. Mazzo, D. Meneghello, C. Mihalcea, E. Milan, M. Montresor, A. Pani, V. Pavani, C. Resentera, M. Residori, P. Righetti, M. A. Ripoli, P. Riscica, C. Rizza, V. Rizzetto, A. Rossi, A. Rovea, A. Ruffato, C. Ruzziconi, N. Sembianti, C. Smacchia, C. Stimolo, E. Zerbetto, M. Zerman

Risultato della ricerca: Contributo in rivista › Articolo in rivista

8 Citazioni (Scopus)

Abstract

Objectives To evaluate prevalence and severity of constipation and quality of life (QoL) in a cohort of opioid-addicted patients treated with opioid substitution treatments (OST). METHODS: A total of 1057 heroin-dependent patients treated with methadone or buprenorphine were enrolled in a multicenter observational study. Constipation was assessed by Wexner Constipation Scoring System (Wexner CSS), QoL by General Health Questionnaire (GHQ-12). RESULTS: 38.5% patients reported mild constipation, 33.3% reported moderate constipation, 14.8% severe constipation and 5.1% very severe constipation. Mean Wexner CSS score was 6.6 ± 4.8. 44.9% patients showed a GHQ-12 score ≥14; of these 18.3% patients showed a GHQ-12 score ≥20. Mean GHQ score was 13.8 ± 6.5. Mean Wexner CSS score was significantly higher in methadone patients (p = 0.004), in those taking psychoactive drugs (p = 0.0001) and in female (p < 0.0001) with respect to counterparts. Similarly, GHQ-12 mean scores were higher methadone group (p = 0.003), in those taking psychoactive drugs (p < 0.0001), and in female (p = 0.039) with respect to counterparts. ANOVA and ANCOVA showed a significant influence of methadone and female gender on Wexner CSS score while psychoactive drugs significantly influenced both tests. CONCLUSIONS: The present study shows that patients affected by opioid-dependence in OST with methadone and buprenorphine have a high prevalence of constipation and reduced QoL.

Lingua originale	English
pagine (da-a)	2135-2141
Numero di pagine	7
Rivista	EXPERT OPINION ON PHARMACOTHERAPY
Stato di pubblicazione	Pubblicato - 2016

Keywords

opioids

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Gasbarrini, A., Addolorato, G., Mirijello, A., Lugoboni, F., Zamboni, L., Faccini, M., Casari, R., Cossari, A., Arzillo, C., Bersani, N., Bersani, P., Biasin, C., Bossi, C., Bottazzo, A., Bove, A., Cantanchin, F., Cantiero, D., Canzian, G., Cargnelutti, D., ... Zerman, M. (2016). High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments. EXPERT OPINION ON PHARMACOTHERAPY, 2135-2141.

Gasbarrini, Antonio ; Addolorato, Giovanni ; Mirijello, Antonio ; Lugoboni, Fabio ; Zamboni, Lorenzo ; Faccini, Marco ; Casari, Rebecca ; Cossari, Anthony ; Arzillo, C. ; Bersani, N. ; Bersani, P. ; Biasin, C. ; Bossi, C. ; Bottazzo, A. ; Bove, A. ; Cantanchin, F. ; Cantiero, D. ; Canzian, G. ; Cargnelutti, D. ; Cibin, M. ; De Cecco, L. ; Dellantonio, E. ; Dersini, F. ; Fadelli, M. ; Favero, E. ; Fontana, N. ; Franceschini, A. ; Gaiga, M. ; Gardiolo, M. ; Gentile, N. ; Ghezzo, N. ; Giacomin, M. A. ; Manzato, E. ; Mazzo, M. ; Meneghello, D. ; Mihalcea, C. ; Milan, E. ; Montresor, M. ; Pani, A. ; Pavani, V. ; Resentera, C. ; Residori, M. ; Righetti, P. ; Ripoli, M. A. ; Riscica, P. ; Rizza, C. ; Rizzetto, V. ; Rossi, A. ; Rovea, A. ; Ruffato, A. ; Ruzziconi, C. ; Sembianti, N. ; Smacchia, C. ; Stimolo, C. ; Zerbetto, E. ; Zerman, M. / High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments. In: EXPERT OPINION ON PHARMACOTHERAPY. 2016 ; pagg. 2135-2141.

@article{56a054f4b5284c30a38dad0692f199ef,

title = "High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments.",

abstract = "Objectives To evaluate prevalence and severity of constipation and quality of life (QoL) in a cohort of opioid-addicted patients treated with opioid substitution treatments (OST). METHODS: A total of 1057 heroin-dependent patients treated with methadone or buprenorphine were enrolled in a multicenter observational study. Constipation was assessed by Wexner Constipation Scoring System (Wexner CSS), QoL by General Health Questionnaire (GHQ-12). RESULTS: 38.5% patients reported mild constipation, 33.3% reported moderate constipation, 14.8% severe constipation and 5.1% very severe constipation. Mean Wexner CSS score was 6.6 ± 4.8. 44.9% patients showed a GHQ-12 score ≥14; of these 18.3% patients showed a GHQ-12 score ≥20. Mean GHQ score was 13.8 ± 6.5. Mean Wexner CSS score was significantly higher in methadone patients (p = 0.004), in those taking psychoactive drugs (p = 0.0001) and in female (p < 0.0001) with respect to counterparts. Similarly, GHQ-12 mean scores were higher methadone group (p = 0.003), in those taking psychoactive drugs (p < 0.0001), and in female (p = 0.039) with respect to counterparts. ANOVA and ANCOVA showed a significant influence of methadone and female gender on Wexner CSS score while psychoactive drugs significantly influenced both tests. CONCLUSIONS: The present study shows that patients affected by opioid-dependence in OST with methadone and buprenorphine have a high prevalence of constipation and reduced QoL.",

keywords = "opioids, opioids",

author = "Antonio Gasbarrini and Giovanni Addolorato and Antonio Mirijello and Fabio Lugoboni and Lorenzo Zamboni and Marco Faccini and Rebecca Casari and Anthony Cossari and C. Arzillo and N. Bersani and P. Bersani and C. Biasin and C. Bossi and A. Bottazzo and A. Bove and F. Cantanchin and D. Cantiero and G. Canzian and D. Cargnelutti and M. Cibin and {De Cecco}, L. and E. Dellantonio and F. Dersini and M. Fadelli and E. Favero and N. Fontana and A. Franceschini and M. Gaiga and M. Gardiolo and N. Gentile and N. Ghezzo and Giacomin, {M. A.} and E. Manzato and M. Mazzo and D. Meneghello and C. Mihalcea and E. Milan and M. Montresor and A. Pani and V. Pavani and C. Resentera and M. Residori and P. Righetti and Ripoli, {M. A.} and P. Riscica and C. Rizza and V. Rizzetto and A. Rossi and A. Rovea and A. Ruffato and C. Ruzziconi and N. Sembianti and C. Smacchia and C. Stimolo and E. Zerbetto and M. Zerman",

year = "2016",

language = "English",

pages = "2135--2141",

journal = "EXPERT OPINION ON PHARMACOTHERAPY",

issn = "1465-6566",

publisher = "-London United Kingdom:Informa Healthcare -London , United Kingdom: Ashley Publications Limited",

}

Gasbarrini, A , Addolorato, G, Mirijello, A, Lugoboni, F, Zamboni, L, Faccini, M, Casari, R, Cossari, A, Arzillo, C, Bersani, N, Bersani, P, Biasin, C, Bossi, C, Bottazzo, A, Bove, A, Cantanchin, F, Cantiero, D, Canzian, G, Cargnelutti, D, Cibin, M, De Cecco, L, Dellantonio, E, Dersini, F, Fadelli, M, Favero, E, Fontana, N, Franceschini, A, Gaiga, M, Gardiolo, M, Gentile, N, Ghezzo, N, Giacomin, MA, Manzato, E, Mazzo, M, Meneghello, D, Mihalcea, C, Milan, E, Montresor, M, Pani, A, Pavani, V, Resentera, C, Residori, M, Righetti, P, Ripoli, MA, Riscica, P, Rizza, C, Rizzetto, V, Rossi, A, Rovea, A, Ruffato, A, Ruzziconi, C, Sembianti, N, Smacchia, C, Stimolo, C, Zerbetto, E & Zerman, M 2016, 'High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments.', EXPERT OPINION ON PHARMACOTHERAPY, pagg. 2135-2141.

High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments. / Gasbarrini, Antonio ; Addolorato, Giovanni; Mirijello, Antonio; Lugoboni, Fabio; Zamboni, Lorenzo; Faccini, Marco; Casari, Rebecca; Cossari, Anthony; Arzillo, C.; Bersani, N.; Bersani, P.; Biasin, C.; Bossi, C.; Bottazzo, A.; Bove, A.; Cantanchin, F.; Cantiero, D.; Canzian, G.; Cargnelutti, D.; Cibin, M.; De Cecco, L.; Dellantonio, E.; Dersini, F.; Fadelli, M.; Favero, E.; Fontana, N.; Franceschini, A.; Gaiga, M.; Gardiolo, M.; Gentile, N.; Ghezzo, N.; Giacomin, M. A.; Manzato, E.; Mazzo, M.; Meneghello, D.; Mihalcea, C.; Milan, E.; Montresor, M.; Pani, A.; Pavani, V.; Resentera, C.; Residori, M.; Righetti, P.; Ripoli, M. A.; Riscica, P.; Rizza, C.; Rizzetto, V.; Rossi, A.; Rovea, A.; Ruffato, A.; Ruzziconi, C.; Sembianti, N.; Smacchia, C.; Stimolo, C.; Zerbetto, E.; Zerman, M.

In: EXPERT OPINION ON PHARMACOTHERAPY, 2016, pag. 2135-2141.

Risultato della ricerca: Contributo in rivista › Articolo in rivista

TY - JOUR

T1 - High prevalence of constipation and reduced quality of life in opioid-dependent patients treated with opioid substitution treatments.

AU - Gasbarrini, Antonio

AU - Addolorato, Giovanni

AU - Mirijello, Antonio

AU - Lugoboni, Fabio

AU - Zamboni, Lorenzo

AU - Faccini, Marco

AU - Casari, Rebecca

AU - Cossari, Anthony

AU - Arzillo, C.

AU - Bersani, N.

AU - Bersani, P.

AU - Biasin, C.

AU - Bossi, C.

AU - Bottazzo, A.

AU - Bove, A.

AU - Cantanchin, F.

AU - Cantiero, D.

AU - Canzian, G.

AU - Cargnelutti, D.

AU - Cibin, M.

AU - De Cecco, L.

AU - Dellantonio, E.

AU - Dersini, F.

AU - Fadelli, M.

AU - Favero, E.

AU - Fontana, N.

AU - Franceschini, A.

AU - Gaiga, M.

AU - Gardiolo, M.

AU - Gentile, N.

AU - Ghezzo, N.

AU - Giacomin, M. A.

AU - Manzato, E.

AU - Mazzo, M.

AU - Meneghello, D.

AU - Mihalcea, C.

AU - Milan, E.

AU - Montresor, M.

AU - Pani, A.

AU - Pavani, V.

AU - Resentera, C.

AU - Residori, M.

AU - Righetti, P.

AU - Ripoli, M. A.

AU - Riscica, P.

AU - Rizza, C.

AU - Rizzetto, V.

AU - Rossi, A.

AU - Rovea, A.

AU - Ruffato, A.

AU - Ruzziconi, C.

AU - Sembianti, N.

AU - Smacchia, C.

AU - Stimolo, C.

AU - Zerbetto, E.

AU - Zerman, M.

PY - 2016

Y1 - 2016

N2 - Objectives To evaluate prevalence and severity of constipation and quality of life (QoL) in a cohort of opioid-addicted patients treated with opioid substitution treatments (OST). METHODS: A total of 1057 heroin-dependent patients treated with methadone or buprenorphine were enrolled in a multicenter observational study. Constipation was assessed by Wexner Constipation Scoring System (Wexner CSS), QoL by General Health Questionnaire (GHQ-12). RESULTS: 38.5% patients reported mild constipation, 33.3% reported moderate constipation, 14.8% severe constipation and 5.1% very severe constipation. Mean Wexner CSS score was 6.6 ± 4.8. 44.9% patients showed a GHQ-12 score ≥14; of these 18.3% patients showed a GHQ-12 score ≥20. Mean GHQ score was 13.8 ± 6.5. Mean Wexner CSS score was significantly higher in methadone patients (p = 0.004), in those taking psychoactive drugs (p = 0.0001) and in female (p < 0.0001) with respect to counterparts. Similarly, GHQ-12 mean scores were higher methadone group (p = 0.003), in those taking psychoactive drugs (p < 0.0001), and in female (p = 0.039) with respect to counterparts. ANOVA and ANCOVA showed a significant influence of methadone and female gender on Wexner CSS score while psychoactive drugs significantly influenced both tests. CONCLUSIONS: The present study shows that patients affected by opioid-dependence in OST with methadone and buprenorphine have a high prevalence of constipation and reduced QoL.

AB - Objectives To evaluate prevalence and severity of constipation and quality of life (QoL) in a cohort of opioid-addicted patients treated with opioid substitution treatments (OST). METHODS: A total of 1057 heroin-dependent patients treated with methadone or buprenorphine were enrolled in a multicenter observational study. Constipation was assessed by Wexner Constipation Scoring System (Wexner CSS), QoL by General Health Questionnaire (GHQ-12). RESULTS: 38.5% patients reported mild constipation, 33.3% reported moderate constipation, 14.8% severe constipation and 5.1% very severe constipation. Mean Wexner CSS score was 6.6 ± 4.8. 44.9% patients showed a GHQ-12 score ≥14; of these 18.3% patients showed a GHQ-12 score ≥20. Mean GHQ score was 13.8 ± 6.5. Mean Wexner CSS score was significantly higher in methadone patients (p = 0.004), in those taking psychoactive drugs (p = 0.0001) and in female (p < 0.0001) with respect to counterparts. Similarly, GHQ-12 mean scores were higher methadone group (p = 0.003), in those taking psychoactive drugs (p < 0.0001), and in female (p = 0.039) with respect to counterparts. ANOVA and ANCOVA showed a significant influence of methadone and female gender on Wexner CSS score while psychoactive drugs significantly influenced both tests. CONCLUSIONS: The present study shows that patients affected by opioid-dependence in OST with methadone and buprenorphine have a high prevalence of constipation and reduced QoL.

KW - opioids

UR - http://hdl.handle.net/10807/92852

M3 - Article

SP - 2135

EP - 2141

JO - EXPERT OPINION ON PHARMACOTHERAPY

JF - EXPERT OPINION ON PHARMACOTHERAPY

SN - 1465-6566

ER -