High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

Federico Biscetti; Giuseppe Straface; Raimondo De Cristofaro; S Lancellotti; P Rizzo; Vincenzo Arena; E Stigliano; Giovanni Pecorini; K Egashira; Giulia De Angelis; G Ghirlanda; Andrea Flex

doi:10.2337/db09-1507

High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

Federico Biscetti^*
, Giuseppe Straface
, Raimondo De Cristofaro
, S Lancellotti
, P Rizzo
, Vincenzo Arena
, E Stigliano
, Giovanni Pecorini
, K Egashira
, Giulia De Angelis
, G Ghirlanda
, Andrea Flex

^*Autore corrispondente per questo lavoro

University of Rome La Sapienza

Risultato della ricerca: Contributo in rivista › Articolo › peer review

84 Citazioni (SciVal)

Abstract

High-mobility group box-1 (HMGB1) protein is a nuclear DNA-binding protein released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. Diabetic human and mouse tissues contain lower levels of HMGB1 than their normoglycemic counterparts. Deficient angiogenesis after ischemia contributes to worse outcomes of peripheral arterial disease in patients with diabetes. To test the hypothesis that HMGB1 enhances ischemia-induced angiogenesis in diabetes, we administered HMGB1 protein in a mouse hind limb ischemia model using diabetic mice.

Lingua originale	Inglese
pagine (da-a)	1496-1505
Numero di pagine	10
Rivista	Diabetes
Volume	59
Numero di pubblicazione	6
DOI	https://doi.org/10.2337/db09-1507
Stato di pubblicazione	Pubblicato - 2010

OSS delle Nazioni Unite

Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile

SDG 3 Salute e benessere

All Science Journal Classification (ASJC) codes

Medicina Interna
Endocrinologia, Diabete e Metabolismo

Keywords

Animals
Blood Flow Velocity
Diabetes Mellitus
Experimental
HMGB1 Protein
Hindlimb
Humans
Inbred C57BL
Ischemia
Male
Mice
Muscle
Neovascularization
Pathologic
Physiologic
Skeletal
Vascular Endothelial Growth Factor A

Accesso al documento

10.2337/db09-1507

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Biscetti, F., Straface, G., De Cristofaro, R., Lancellotti, S., Rizzo, P., Arena, V., Stigliano, E., Pecorini, G., Egashira, K., De Angelis, G., Ghirlanda, G., & Flex, A. (2010). High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism. Diabetes, 59(6), 1496-1505. https://doi.org/10.2337/db09-1507

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abstract = "High-mobility group box-1 (HMGB1) protein is a nuclear DNA-binding protein released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. Diabetic human and mouse tissues contain lower levels of HMGB1 than their normoglycemic counterparts. Deficient angiogenesis after ischemia contributes to worse outcomes of peripheral arterial disease in patients with diabetes. To test the hypothesis that HMGB1 enhances ischemia-induced angiogenesis in diabetes, we administered HMGB1 protein in a mouse hind limb ischemia model using diabetic mice.",

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author = "Federico Biscetti and Giuseppe Straface and \{De Cristofaro\}, Raimondo and S Lancellotti and P Rizzo and Vincenzo Arena and E Stigliano and Giovanni Pecorini and K Egashira and \{De Angelis\}, Giulia and G Ghirlanda and Andrea Flex",

year = "2010",

doi = "10.2337/db09-1507",

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publisher = "American Diabetes Association Inc.",

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Biscetti, F, Straface, G, De Cristofaro, R, Lancellotti, S, Rizzo, P, Arena, V, Stigliano, E, Pecorini, G, Egashira, K, De Angelis, G, Ghirlanda, G & Flex, A 2010, 'High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism', Diabetes, vol. 59, n. 6, pagg. 1496-1505. https://doi.org/10.2337/db09-1507

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T1 - High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

AU - Biscetti, Federico

AU - Straface, Giuseppe

AU - De Cristofaro, Raimondo

AU - Lancellotti, S

AU - Rizzo, P

AU - Arena, Vincenzo

AU - Stigliano, E

AU - Pecorini, Giovanni

AU - Egashira, K

AU - De Angelis, Giulia

AU - Ghirlanda, G

AU - Flex, Andrea

PY - 2010

Y1 - 2010

N2 - High-mobility group box-1 (HMGB1) protein is a nuclear DNA-binding protein released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. Diabetic human and mouse tissues contain lower levels of HMGB1 than their normoglycemic counterparts. Deficient angiogenesis after ischemia contributes to worse outcomes of peripheral arterial disease in patients with diabetes. To test the hypothesis that HMGB1 enhances ischemia-induced angiogenesis in diabetes, we administered HMGB1 protein in a mouse hind limb ischemia model using diabetic mice.

AB - High-mobility group box-1 (HMGB1) protein is a nuclear DNA-binding protein released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. Diabetic human and mouse tissues contain lower levels of HMGB1 than their normoglycemic counterparts. Deficient angiogenesis after ischemia contributes to worse outcomes of peripheral arterial disease in patients with diabetes. To test the hypothesis that HMGB1 enhances ischemia-induced angiogenesis in diabetes, we administered HMGB1 protein in a mouse hind limb ischemia model using diabetic mice.

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KW - Mice

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High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

Abstract

OSS delle Nazioni Unite

All Science Journal Classification (ASJC) codes

Keywords

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