High-mobility group box-1 protein promotes angiogenesis after peripheral ischemia in diabetic mice through a VEGF-dependent mechanism

Raimondo De Cristofaro, Vincenzo Arena, Federico Biscetti, Giuseppe Straface, Kensuke Egashira

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

83 Citazioni (Scopus)

Abstract

High-mobility group box-1 (HMGB1) protein is a nuclear DNA-binding protein released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. Diabetic human and mouse tissues contain lower levels of HMGB1 than their normoglycemic counterparts. Deficient angiogenesis after ischemia contributes to worse outcomes of peripheral arterial disease in patients with diabetes. To test the hypothesis that HMGB1 enhances ischemia-induced angiogenesis in diabetes, we administered HMGB1 protein in a mouse hind limb ischemia model using diabetic mice.
Lingua originaleEnglish
pagine (da-a)1496-1505
Numero di pagine10
RivistaDiabetes
Volume59
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Animals
  • Blood Flow Velocity
  • Diabetes Mellitus, Experimental
  • HMGB1 Protein
  • Hindlimb
  • Humans
  • Ischemia
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Muscle, Skeletal
  • Neovascularization, Pathologic
  • Neovascularization, Physiologic
  • Vascular Endothelial Growth Factor A

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