High mobility group box-1 and diabetes mellitus complications: State of the art and future perspectives

Giovanni Pecorini, Andrea Flex, Federico Biscetti, Elisabetta Nardella, Andrea Leonardo Cecchini, Raffaele Landolfi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

Diabetes mellitus (DM) is an endemic disease, with growing health and social costs. The complications of diabetes can affect potentially all parts of the human body, from the heart to the kidneys, peripheral and central nervous system, and the vascular bed. Although many mechanisms have been studied, not all players responsible for these complications have been defined yet. High Mobility Group Box-1 (HMGB1) is a non-histone nuclear protein that has been implicated in many pathological processes, from sepsis to ischemia. The purpose of this review is to take stock of all the most recent data available on the role of HMGB1 in the complications of DM.
Lingua originaleEnglish
pagine (da-a)6258-N/A
RivistaInternational Journal of Molecular Sciences
Volume20
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Animals
  • Diabetes Complications
  • Diabetes mellitus
  • HMGB1 Protein
  • High Mobility Group Box-1 (HMGB1)
  • Humans
  • Models, Biological
  • Vascular complications

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