High-Dose-Rate Interstitial Brachytherapy (Interventional Radiotherapy) for Conjunctival Melanoma with Orbital Extension

Monica Maria Pagliara, Luca Tagliaferri, Gustavo Savino, Bruno Fionda, Andrea D'Aviero, Angela Lanza, Gaetano Antonio Lanza, Valentina Lancellotta, Giulia Midena, Maria Antonietta Gambacorta, Maria Antonietta Blasi

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Purpose: To evaluate local control and functional and cosmetic outcomes of postoperative high-dose-rate interventional radiotherapy (HDR-IRT) in patients affected by conjunctival melanoma with orbit invasion. Methods: A retrospective study was conducted in 2 patients affected by conjunctival melanoma infiltrating the orbit, treated with surgical excision and HDR-IRT. The treatment procedures consisted of surgical excision of the orbital infiltrating nodule followed, 1 month after surgery, by adjuvant HDR-IRT. A target dose of 34 Gy was delivered in 10 twice-a-day fractions over 5 consecutive days. Data analysis included local tumor control and metastatic rate, acute and late toxicity, functional and aesthetic results. Results: In both patients, treatment was well tolerated, and there was no orbital recurrence at a median follow-up of 37-40 months. There was an excellent functional outcome, without no significant acute or late side effects. Conclusions: HDR-IRT could be considered a promising, feasible, successful, and well-tolerated option for selected patients affected by ocular tumors with orbital invasion.
Lingua originaleEnglish
pagine (da-a)199-205
Numero di pagine7
RivistaOcular Oncology and Pathology
Stato di pubblicazionePubblicato - 2021


  • Brachytherapy
  • Conjunctival melanoma
  • Ocular oncology
  • Ocular tumors
  • Ophthalmic oncology


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