Heterogeneity of root and nerve ultrasound pattern in CIDP patients

Luca Padua, Mario Sabatelli, Giuseppe Granata, Marco Luigetti, M. Inghilleri, M. Lucchetta, D. Coraci, C. Martinoli, C. Briani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

104 Citazioni (Scopus)

Abstract

Objective: The few published ultrasound (US) studies on chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) report diffusely increased cross-sectional area (CSA) of nerves. The data are, however, heterogeneous and correlations with clinical history or disease severity are lacking. Methods: Thirty-four patients with CIDP underwent US nerve evaluation by two neurologists blinded to clinical data. US nerve pattern for each patient was defined by a third neurologist blinded to clinical data. Three US classes were identified based on CSA and echogenicity: large nerves with hypoechoic nerves/ fascicles (class 1); large nerves with heterogeneous hypo- and hyperechoic fascicles (class 2); normal size nerve but abnormal hyperechoic array (class 3). Results: In all patients, US nerve changes were observed: in most of the cases, enlarged nerves or nerve segments were observed. The three ‘classes’ of US nerve changes significantly correlated (R: 0.68, p < 0.001) with disease duration, but not with age or Inflammatory Neuropathy Cause and Treatment (INCAT) disability score. Conclusions: US may be of adjunctive diagnostic value in CIDP assessment. Nerve morphological changes may mirror the underlying pathophysiological mechanisms and seem to correlate with disease duration. Significance: These results offer the possibility of exploring the use of US to assess CIDP disease activity and treatment.
Lingua originaleEnglish
pagine (da-a)160-165
Numero di pagine6
RivistaClinical Neurophysiology
Volume125
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Autoimmune diseases
  • Chronic inflammatory demyelinating polineuropathy
  • Peripheral neuropathy
  • Ultrasound

Fingerprint

Entra nei temi di ricerca di 'Heterogeneity of root and nerve ultrasound pattern in CIDP patients'. Insieme formano una fingerprint unica.

Cita questo