TY - JOUR
T1 - Herpes Simplex Virus-1 in the Brain: The Dark Side of a Sneaky Infection
AU - Marcocci, Maria Elena
AU - Napoletani, Giorgia
AU - Protto, Virginia
AU - Kolesova, Olga
AU - Piacentini, Roberto
AU - Li Puma, Domenica Donatella
AU - Lomonte, Patrick
AU - Grassi, Claudio
AU - Palamara, Anna Teresa
AU - De Chiara, Giovanna
PY - 2020
Y1 - 2020
N2 - Herpes simplex virus-1 (HSV-1) establishes latency preferentially in sensory neurons of peripheral ganglia. A variety of stresses can induce recurrent reactivations of the virus, which spreads and then actively replicates to the site of primary infection (usually the lips or eyes). Viral particles produced following reactivation can also reach the brain, causing a rare but severe form of diffuse acute infection, namely herpes simplex encephalitis. Most of the time, this infection is clinically asymptomatic. However, it was recently correlated with the production and accumulation of neuropathological biomarkers of Alzheimer's disease. In this review we discuss the different cellular and molecular mechanisms underlying the acute and long-term damage caused by HSV-1 infection in the brain.
AB - Herpes simplex virus-1 (HSV-1) establishes latency preferentially in sensory neurons of peripheral ganglia. A variety of stresses can induce recurrent reactivations of the virus, which spreads and then actively replicates to the site of primary infection (usually the lips or eyes). Viral particles produced following reactivation can also reach the brain, causing a rare but severe form of diffuse acute infection, namely herpes simplex encephalitis. Most of the time, this infection is clinically asymptomatic. However, it was recently correlated with the production and accumulation of neuropathological biomarkers of Alzheimer's disease. In this review we discuss the different cellular and molecular mechanisms underlying the acute and long-term damage caused by HSV-1 infection in the brain.
KW - Alzheimer's disease
KW - HSV-1
KW - encephalitis
KW - herpes simplex virus-1
KW - neurodegeneration latency/reactivation
KW - Alzheimer's disease
KW - HSV-1
KW - encephalitis
KW - herpes simplex virus-1
KW - neurodegeneration latency/reactivation
UR - http://hdl.handle.net/10807/181643
U2 - 10.1016/j.tim.2020.03.003
DO - 10.1016/j.tim.2020.03.003
M3 - Article
SN - 0966-842X
VL - 28
SP - 808
EP - 820
JO - Trends in Microbiology
JF - Trends in Microbiology
ER -