HER2 status determination: Analyzing the problems to find the solutions

Vincenzo Arena, Ilaria Pennacchia, Irene Terrenato, Simonetta Buglioni, Marcella Mottolese

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

2 Citazioni (Scopus)

Abstract

Misdiagnosis in the evaluation of HER2 status in breast cancer may have consequent negative impact on clinical decision-making. Therefore, it has become ever more important to share procedures and interpretation criteria for HER2 testing among laboratories. Herein, we report an interlaboratory survey among 9 hospitals located in the central-south regions of Italy. The centers sent a series of 36 slides, 4 for each HER2 score, to the revising centers. We found a good concordance in HER2 scoring for 0 and 3+ score, but a very low concordance for 1+ and 2+ scores. To focus on factors that may lead to discordant results, we report 4 cases which summarized the most common source of discrepancy in HER2 testing. This methodological approach will help the individual laboratory to minimize technical variables and to reduce the percentage of erroneous interpretations of HER2 status.
Lingua originaleEnglish
pagine (da-a)645-651
Numero di pagine7
RivistaMEDICINE
Volume94
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Breast Neoplasms
  • Female
  • Genetic Techniques
  • Humans
  • Immunohistochemistry
  • Medicine (all)
  • Observer Variation
  • Receptor, ErbB-2
  • Reproducibility of Results

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