Hepatocellular carcinoma recurrence in patients with curative resection or ablation: impact of HCV eradication does not depend on the use of interferon

Gian Ludovico Rapaccini, Antonio Gasbarrini, Maurizio Pompili, Antonio Gasbarrini, Nicoletta De Matthaeis, Emanuele Rinninella, S. Petta, G. Cabibbo, M. Barbara, S. Attardo, L. Bucci, F. Farinati, E. G. Giannini, F. Tovoli, F. Ciccarese, G. L. Rapaccini, M. Di Marco, E. Caturelli, M. Zoli, F. BorzioR. Sacco, R. Virdone, F. Marra, M. Felder, F. Morisco, L. Benvegnù, G. Svegliati-Baroni, F. G. Foschi, A. Olivani, A. Masotto, G. Nardone, A. Colecchia, M. Persico, V. Boccaccio, A. Craxì, S. Bruno, F. Trevisani, C. Cammà, Maurizio Biselli, Paolo Caraceni, Alessandro Cucchetti, Marco Domenicali, Fabio Piscaglia, Annagiulia Gramenzi, Alessandro Granito, Donatella Magalotti, Carla Serra, Giulia Negrini, Lucia Napoli, Veronica Salvatore, Francesca Benevento, Alessia Gazzola, Francesca Murer, Caterina Pozzan, Veronica Vanin, Alessandro Moscatelli, Gaia Pellegatta, Antonino Picciotto, Vincenzo Savarino, Paolo Delpoggio, Stefano Olmi, Nicoletta Dematthaeis, Claudia Balsamo, Elena Vavassori, Paola Roselli, Serena Dell’Isola, Anna Maria Ialungo, Elena Rastrelli, Francesca Rini, Andrea Costantino, Andrea Affronti, Marco Affronti, Marta Mascari, Andrea Mega, Valeria Mismas, Anna Chiara Dall’Aglio, Valentina Feletti, Arianna Lanzi, Federica Mirici Cappa, Elga Neri, Giuseppe Francesco Stefanini, Stefano Tamberi, Elisabetta Biasini, Gabriele Missale, Maria Guarino, Alessio Ortolani, Maria Chiaramonte, Fabiana Marchetti, Matteo Valerio, Sami Aburas, Andrea L. Inghilesi, Alberta Cappelli, Rita Golfieri, Cristina Mosconi, Matteo Renzulli, Piero Coccoli, Marco Sanduzzi Zamparelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

55 Citazioni (Scopus)

Abstract

Background: In HCV-infected cirrhotic patients with successfully treated early hepatocellular carcinoma (HCC), the time to HCC recurrence and the effects of sustained viral eradication (SVR) by interferon (IFN)-based or IFN-free regimens on HCC recurrence remain unclear. Aim: To perform an indirect comparison of time to recurrence (TTR) in patients with successfully treated early HCC and active HCV infection with those of patients with SVR by IFN-based and by IFN-free regimens. Methods: We evaluated 443 patients with HCV-related cirrhosis and Barcelona Clinic Liver Cancer Stage A/0 HCC who had a complete radiological response after curative resection or ablation. Active HCV infection was present in 328, selected from the Italian Liver Cancer group cohort; 58 patients had SVR achieved by IFN-free regimens after HCC cure, and 57 patients had SVR achieved by IFN-based regimens after HCC cure. Individual data of patients in the last two groups were extracted from available publications. Results: TTR by Kaplan–Meier curve was significantly lower in patients with active HCV infection compared with those with SVR both by IFN-free (P = 0.02) and by IFN-based (P < 0.001) treatments. TTR was similar in patients with SVR by IFN-free or by IFN-based (P = 0.49) strategies. Conclusion: In HCV-infected, successfully treated patients with early HCC, SVR obtained by IFN-based or IFN-free regimens significantly reduce tumour recurrence without differences related to the anti-viral strategy used.
Lingua originaleEnglish
pagine (da-a)160-168
Numero di pagine9
RivistaALIMENTARY PHARMACOLOGY &amp; THERAPEUTICS
Volume45
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Pharmacology (medical)

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