Heparin and low-dose aspirin restore placental human chorionic gonadotrophin secretion abolished by antiphospholipid antibody-containing sera

Nicoletta Di Simone, Sergio Ferrazzani, Sara De Carolis, Salvatore Mancuso, Alessandro Caruso

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

56 Citazioni (Scopus)

Abstract

This study was conducted to determine whether drugs used for conventional treatments of pregnant women with antiphosholipid syndrome might be able to restore the gonadotrophin-releasing hormone (GnRH)-induced secretion of placental human chorionic gonadotrophin (HCG) in vitro. We tested this hypothesis using a modified enzyme-linked immunosorbent assay (ELISA) and an in-vitro placental culture system. Pharmacological dose of low molecular weight heparin (20 IU/ml) significantly (P < 0.02) reduced the antiphospholipid antibody (aPL) binding in the ELISA and was able to restore GnRH-induced HCG secretion (P < 0.05) in presence of aPL-containing sera. Low-dose aspirin (0.03 M) did not modify aPL binding in the ELISA, but partially restored HCG secretion (P < 0.05). These observations may help to explain the role of these treatments in antiphospholipid syndrome.
Lingua originaleEnglish
pagine (da-a)2061-2065
Numero di pagine5
RivistaHuman Reproduction
DOI
Stato di pubblicazionePubblicato - 1997

Keywords

  • Acetil Salicilic acid
  • Antibodies, Antiphospholipid
  • Gonadotropinic Hormone
  • Pregnancy
  • Trophoblasts

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