Hemodynamic evaluation of the optic nerve head in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

Aldo Caporossi, Alessandra Rufa, Maria Teresa Dotti, Paolo Frezzotti, Nicola De Stefano, Antonio Federico

Risultato della ricerca: Contributo in rivistaArticolo in rivista

16 Citazioni (Scopus)

Abstract

Background: Although cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is considered a cerebrovascular disorder with almost exclusively neurological symptoms, arteriopathy is generalized and also involves the choroid and retina. Objective. To study optic nerve head microvascular function in CADASIL by assessing blood flow, volume, and velocity with a retina flowmeter. Patients and Methods: Scanning laser Doppler flowmetry permits the noninvasive assessment of relative blood velocity, volume, and flow in a sample volume of either retina or anterior optic nerve head. Measurements were performed in a first group of 9 eyes of 5 patients with CADASIL and a second group of 8 eyes of 4 healthy subjects. Hemodynamic parameters were computed in 4 quadrants of the optic disc (superior nasal, superior temporal, inferior nasal, and inferior temporal). The Wilcoxon rank sum test was used to assess differences in relative flow, volume, and velocity in each quadrant and between the 2 groups and differences in overall optic nerve head blood flow, volume, and velocity. Results. Patients with CADASIL had a significant decrease in overall blood flow and volume compared with healthy subjects (P <.05). The reduction in blood flow and volume was particularly significant in the superior and inferior temporal quadrants. No significant differences were found nasally between the patients and the control groups. Conclusion. Our results suggest that hemodynamic parameters are abnormal in the superficial nerve fiber layer of the optic nerve head of patients with CADASIL, especially in the temporal quadrants of the neuroretinal rim.
Lingua originaleEnglish
pagine (da-a)1230-1233
Numero di pagine4
RivistaArchives of Neurology
Volume61
DOI
Stato di pubblicazionePubblicato - 2004

Keywords

  • Adult
  • Arts and Humanities (miscellaneous)
  • Cerebral Infarction
  • Dementia, Multi-Infarct
  • Dementia, Vascular
  • Female
  • Hemodynamics
  • Humans
  • Laser-Doppler Flowmetry
  • Male
  • Microcirculation
  • Middle Aged
  • Neurology (clinical)
  • Optic Disk
  • Retina
  • Statistics, Nonparametric
  • Visual Fields

Fingerprint

Entra nei temi di ricerca di 'Hemodynamic evaluation of the optic nerve head in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy'. Insieme formano una fingerprint unica.

Cita questo