Helicobacter pylori infection: Is sequential therapy superior to standard triple therapy? A single-centre Italian study in treatment-naive and non-treatment-naive patients

R. Urgesi, G. Pelecca, Rossella Cianci, A. Masini, C. Zampaletta, Maria Elena Riccioni, R. Faggiani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

BACKGROUND: Clarithromycin resistance has decreased the eradication rates of Helicobacter pylori. AIMS: To determine whether a 10-day course of sequential therapy (ST) is more effective at eradicating H pylori infection than triple therapy (TT) in the first or second line, and to assess side effects and compliance with therapy. METHODS: One hundred sixty treatment-naive and 40 non-treatmentnaive patients who were positive for H pylori infection by 13C-urea breath test or endoscopy were enrolled. Eighty of 160 patients underwent TT, while 80 of 160 underwent ST with omeprazole (20 mg) plus amoxicillin (1 g) twice/day for five days, followed by omeprazole (20 mg) with tinidazole (500 mg) twice/day and clarithromycin (500 mg) twice/day for five consecutive days. H pylori eradication was evaluated by 13C-urea breath test no sooner than four weeks after the end of treatment. RESULTS: Eradication was achieved in 59 of 80 treatment-naive patients treated with TT (74%), in 74 of 80 patients treated with ST (93%), and in 38 of 40 non-treatment-naive patients (95%). Eradication rates in treatment-naive patients with ST were statistically significantly higher than TT (92.5% versus 73.7%; P=0.0015; OR 4.39 [95% CI 1.66 to 11.58]). Mild adverse effects were reported for both regimens. CONCLUSIONS: ST appears to be a well-tolerated, promising therapy; however, randomized controlled trials with larger and more diverse sample populations are needed before it can be recommended as a first-line treatment. ©2011 Pulsus Group Inc. All rights reserved.
Lingua originaleEnglish
pagine (da-a)315-318
Numero di pagine4
RivistaTHE CANADIAN JOURNAL OF GASTROENTEROLOGY
Volume25
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Helicobacter pylori
  • Sequential therapy
  • Standard therapy

Fingerprint

Entra nei temi di ricerca di 'Helicobacter pylori infection: Is sequential therapy superior to standard triple therapy? A single-centre Italian study in treatment-naive and non-treatment-naive patients'. Insieme formano una fingerprint unica.

Cita questo