Helicobacter pylori antibiotic resistance and [13C]urea breath test values

Francesco Perna, Cesare Hassan, V De Francesco, A Zullo, F Giorgio, L Vannella, F Cristofari, C Panella, D Vaira, E. Ierardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

A correlation between delta over baseline (DOB) values of the [(13)C]urea breath test (UBT) and Helicobacter pylori clarithromycin resistance has been reported, suggesting a possible predictive role of UBT in therapeutic outcome. However, available data are limited and conflicting. This study aimed to clarify this issue, assessing the possible relationship between H. pylori resistance towards different antibiotics (clarithromycin, metronidazole and levofloxacin) and UBT values. The data showed similar DOB values between susceptible and resistant strains for clarithromycin (46.9+/-32.3 vs 45.7+/-30.6; P=0.8), metronidazole (46.4+/-29.6 vs 47.4+/-37.9; P=0.8), and levofloxacin (45.0+/-30.2 vs 54.2+/-38.4; P=0.08). Likewise, comparable DOB values were observed between susceptible and multidrug-resistant strains (45.4+/-29.6 vs 54.8+/-44.8; P=0.1). In conclusion, our data failed to find a significant correlation between UBT values and H. pylori antibiotic resistance.
Lingua originaleEnglish
pagine (da-a)588-591
Numero di pagine4
RivistaJournal of Medical Microbiology
Volume59
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Adult
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Breath Tests
  • Clarithromycin
  • Drug Resistance, Bacterial
  • Female
  • Helicobacter pylori
  • Humans
  • Male
  • Metronidazole
  • Middle Aged
  • Ofloxacin
  • Statistics as Topic
  • Urea
  • Urease

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