Health-related Quality of Life After Radical Cystectomy: A Cross-sectional Study With Matched-pair Analysis on Ileal Conduit vs Ileal Orthotopic Neobladder Diversion

Maria Angela Cerruto, Carolina D'Elia, Salvatore Siracusano, Omar Saleh, Mauro Gacci, Giovanni Cacciamani, Vincenzo De Marco, Antonio Benito Porcaro, Matteo Balzarro, Mauro Niero, Cristina Lonardi, Massimo Iafrate, Pierfrancesco Bassi, Ciro Imbimbo, Marco Racioppi, Renato Talamini, Stefano Ciciliato, Sergio Serni, Marco Carini, Paolo VerzeWalter Artibani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)


Objective To examine the different and health-related quality of life (HR-QoL) outcomes between ileal conduit (IC) and ileal orthotopic neobladder (IONB) in patients who underwent radical cystectomy (RC), by using validated self-reported cancer-specific instruments. Patients and Methods This retrospective, cross-sectional, multicenter cohort study included 148 and 171 patients with either IC or IONB. HR-QoL was evaluated with Quality of Life Core Questionnaire and bladder module (BLM)-30 European Organisation for Research and Treatment of Cancer questionnaires. Baseline HR-QoL scores were dichotomized at the median to give “good” or “poor” score profiles. A matched-pair analysis compared HR-QoL aspects between 79 IC patients and 79 IONB patients. Results At univariate analysis IONB resulted favorable for physical functioning, emotional functioning, cognitive functioning (CF), fatigue, dyspnea, appetite loss, constipation (CO), and abdominal bloating flatulence (AB). At multivariate analyses, IONB showed better scores for emotional functioning (85 vs 79, P =.023), CF (93 vs 85, P <.001), CO (16 vs 31, P <.001), and AB (12 vs 25, P <.001). A significant worsening of sexual and urinary function was observed for IONB patients in the long-term. At matched-pair analysis, global health status was similar (65 vs 62, P =.385). Significantly better scores were observed in the IONB group for the following items: CF (P =.007), fatigue (P =.003), pain (P =.019), dyspnea (P =.016), CO (P =.001), and AB (P =.00). Conclusion IONB and IC after RC were similar in terms of global health status. IONB provides better results in some aspects of HR-QoL related to bowel function, but a worsening of urinary and sexual functions. Further randomized controlled trials are needed to confirm these data.
Lingua originaleEnglish
pagine (da-a)82-89
Numero di pagine8
Stato di pubblicazionePubblicato - 2017


  • Aged
  • Cross-Sectional Studies
  • Cystectomy
  • Female
  • Follow-Up Studies
  • Health Status
  • Humans
  • Male
  • Matched-Pair Analysis
  • Middle Aged
  • Quality of Life
  • Retrospective Studies
  • Surveys and Questionnaires
  • Treatment Outcome
  • Urinary Bladder
  • Urinary Bladder Neoplasms
  • Urinary Diversion
  • Urinary Reservoirs, Continent
  • Urination


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