HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

Tiina Santonen; Simo P. Porras; Beatrice Bocca; Radia Bousoumah; Radu Corneliu Duca; Karen S. Galea; Lode Godderis; Thomas Göen; Emilie Hardy; Ivo Iavicoli; Beata Janasik; Kate Jones; Elizabeth Leese; Veruscka Leso; Henriqueta Louro; Nicole Majery; Sophie Ndaw; Hermínia Pinhal; Flavia Ruggieri; Maria J. Silva; An Van Nieuwenhuyse; Jelle Verdonck; Susana Viegas; Wojciech Wasowicz; Ovnair Sepai; Paul T.J. Scheepers; Kukka Aimonen; Guillaume Antoine; Rob Anzion; Manuella Burgart; Argelia Castaño; Andrea Cattaneo; Domenico Maria Cavallo; Giuseppe De Palma; Flavien Denis; Angela Gambelunghe; Bruno Gomes; Ogier Hanser; Riikka Helenius; Carina Ladeira; Marta Esteban López; Piero Lovreglio; Philippe Marsan; Mathieu Melczer; Ana Nogueira; Elisabeta Pletea; Katrien Poels; Jouko Remes; Edna Ribeiro; Sílvia Reis Santos; Françoise Schaefers; Sally Spankie; Robert Spoek; Mohamed Rizki; Davy Rousset; Maurice Van Dael; Henna Veijalainen

doi:10.1016/j.envres.2021.111984

HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

Tiina Santonen, Simo P. Porras, Beatrice Bocca, Radia Bousoumah, Radu Corneliu Duca, Karen S. Galea, Lode Godderis, Thomas Göen, Emilie Hardy, Ivo Iavicoli, Beata Janasik, Kate Jones, Elizabeth Leese, Veruscka Leso, Henriqueta Louro, Nicole Majery, Sophie Ndaw, Hermínia Pinhal, Flavia Ruggieri, Maria J. SilvaAn Van Nieuwenhuyse, Jelle Verdonck, Susana Viegas, Wojciech Wasowicz, Ovnair Sepai, Paul T.J. Scheepers, Kukka Aimonen, Guillaume Antoine, Rob Anzion, Manuella Burgart, Argelia Castaño, Andrea Cattaneo, Domenico Maria Cavallo, Giuseppe De Palma, Flavien Denis, Angela Gambelunghe, Bruno Gomes, Ogier Hanser, Riikka Helenius, Carina Ladeira, Marta Esteban López, Piero Lovreglio, Philippe Marsan, Mathieu Melczer, Ana Nogueira, Elisabeta Pletea, Katrien Poels, Jouko Remes, Edna Ribeiro, Sílvia Reis Santos, Françoise Schaefers, Sally Spankie, Robert Spoek, Mohamed Rizki, Davy Rousset, Maurice Van Dael, Henna Veijalainen

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

Abstract

Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.

Lingua originale	English
pagine (da-a)	111984-N/A
Rivista	Environmental Research
Volume	204
DOI	https://doi.org/10.1016/j.envres.2021.111984
Stato di pubblicazione	Pubblicato - 2022

Keywords

Biomonitoring
Electroplating
Welding
Occupational exposure
Hexavalent chromium

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10.1016/j.envres.2021.111984

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Santonen, T., Porras, S. P., Bocca, B., Bousoumah, R., Duca, R. C., Galea, K. S., Godderis, L., Göen, T., Hardy, E., Iavicoli, I., Janasik, B., Jones, K., Leese, E., Leso, V., Louro, H., Majery, N., Ndaw, S., Pinhal, H., Ruggieri, F., ... Veijalainen, H. (2022). HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium. Environmental Research, 204, 111984-N/A. https://doi.org/10.1016/j.envres.2021.111984

@article{961bd89df5184097a9d47f577eab2744,

title = "HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium",

abstract = "Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.",

keywords = "Biomonitoring, Electroplating, Welding, Occupational exposure, Hexavalent chromium, Biomonitoring, Electroplating, Welding, Occupational exposure, Hexavalent chromium",

author = "Tiina Santonen and Porras, {Simo P.} and Beatrice Bocca and Radia Bousoumah and Duca, {Radu Corneliu} and Galea, {Karen S.} and Lode Godderis and Thomas G{\"o}en and Emilie Hardy and Ivo Iavicoli and Beata Janasik and Kate Jones and Elizabeth Leese and Veruscka Leso and Henriqueta Louro and Nicole Majery and Sophie Ndaw and Herm{\'i}nia Pinhal and Flavia Ruggieri and Silva, {Maria J.} and {Van Nieuwenhuyse}, An and Jelle Verdonck and Susana Viegas and Wojciech Wasowicz and Ovnair Sepai and Scheepers, {Paul T.J.} and Kukka Aimonen and Guillaume Antoine and Rob Anzion and Manuella Burgart and Argelia Casta{\~n}o and Andrea Cattaneo and Cavallo, {Domenico Maria} and {De Palma}, Giuseppe and Flavien Denis and Angela Gambelunghe and Bruno Gomes and Ogier Hanser and Riikka Helenius and Carina Ladeira and L{\'o}pez, {Marta Esteban} and Piero Lovreglio and Philippe Marsan and Mathieu Melczer and Ana Nogueira and Elisabeta Pletea and Katrien Poels and Jouko Remes and Edna Ribeiro and Santos, {S{\'i}lvia Reis} and Fran{\c c}oise Schaefers and Sally Spankie and Robert Spoek and Mohamed Rizki and Davy Rousset and {Van Dael}, Maurice and Henna Veijalainen",

year = "2022",

doi = "10.1016/j.envres.2021.111984",

language = "English",

volume = "204",

pages = "111984--N/A",

journal = "Environmental Research",

issn = "0013-9351",

publisher = "Academic Press Inc.",

}

Santonen, T, Porras, SP, Bocca, B, Bousoumah, R, Duca, RC, Galea, KS, Godderis, L, Göen, T, Hardy, E, Iavicoli, I, Janasik, B, Jones, K, Leese, E, Leso, V, Louro, H, Majery, N, Ndaw, S, Pinhal, H, Ruggieri, F, Silva, MJ, Van Nieuwenhuyse, A, Verdonck, J, Viegas, S, Wasowicz, W, Sepai, O, Scheepers, PTJ, Aimonen, K, Antoine, G, Anzion, R, Burgart, M, Castaño, A, Cattaneo, A, Cavallo, DM, De Palma, G, Denis, F, Gambelunghe, A, Gomes, B, Hanser, O, Helenius, R, Ladeira, C, López, ME, Lovreglio, P, Marsan, P, Melczer, M, Nogueira, A, Pletea, E, Poels, K, Remes, J, Ribeiro, E, Santos, SR, Schaefers, F, Spankie, S, Spoek, R, Rizki, M, Rousset, D, Van Dael, M & Veijalainen, H 2022, 'HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium', Environmental Research, vol. 204, pagg. 111984-N/A. https://doi.org/10.1016/j.envres.2021.111984

TY - JOUR

T1 - HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

AU - Santonen, Tiina

AU - Porras, Simo P.

AU - Bocca, Beatrice

AU - Bousoumah, Radia

AU - Duca, Radu Corneliu

AU - Galea, Karen S.

AU - Godderis, Lode

AU - Göen, Thomas

AU - Hardy, Emilie

AU - Iavicoli, Ivo

AU - Janasik, Beata

AU - Jones, Kate

AU - Leese, Elizabeth

AU - Leso, Veruscka

AU - Louro, Henriqueta

AU - Majery, Nicole

AU - Ndaw, Sophie

AU - Pinhal, Hermínia

AU - Ruggieri, Flavia

AU - Silva, Maria J.

AU - Van Nieuwenhuyse, An

AU - Verdonck, Jelle

AU - Viegas, Susana

AU - Wasowicz, Wojciech

AU - Sepai, Ovnair

AU - Scheepers, Paul T.J.

AU - Aimonen, Kukka

AU - Antoine, Guillaume

AU - Anzion, Rob

AU - Burgart, Manuella

AU - Castaño, Argelia

AU - Cattaneo, Andrea

AU - Cavallo, Domenico Maria

AU - De Palma, Giuseppe

AU - Denis, Flavien

AU - Gambelunghe, Angela

AU - Gomes, Bruno

AU - Hanser, Ogier

AU - Helenius, Riikka

AU - Ladeira, Carina

AU - López, Marta Esteban

AU - Lovreglio, Piero

AU - Marsan, Philippe

AU - Melczer, Mathieu

AU - Nogueira, Ana

AU - Pletea, Elisabeta

AU - Poels, Katrien

AU - Remes, Jouko

AU - Ribeiro, Edna

AU - Santos, Sílvia Reis

AU - Schaefers, Françoise

AU - Spankie, Sally

AU - Spoek, Robert

AU - Rizki, Mohamed

AU - Rousset, Davy

AU - Van Dael, Maurice

AU - Veijalainen, Henna

PY - 2022

Y1 - 2022

N2 - Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.

AB - Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was to provide EU relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.

KW - Biomonitoring

KW - Electroplating

KW - Welding

KW - Occupational exposure

KW - Hexavalent chromium

KW - Biomonitoring

KW - Electroplating

KW - Welding

KW - Occupational exposure

KW - Hexavalent chromium

UR - http://hdl.handle.net/10807/308260

U2 - 10.1016/j.envres.2021.111984

DO - 10.1016/j.envres.2021.111984

M3 - Article

SN - 0013-9351

VL - 204

SP - 111984-N/A

JO - Environmental Research

JF - Environmental Research

ER -

HBM4EU chromates study - Overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

Abstract

Keywords

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