Harmful effects and potential benefits of anti-tumor necrosis factor (TNF)-α on the liver

Alessandro Armuzzi, Antonio Gasbarrini, Alfredo Papa, Loris Riccardo Lopetuso, Luisa Guidi, Giammarco Mocci

Risultato della ricerca: Contributo in rivistaArticolo in rivista

19 Citazioni (Scopus)


Anti-tumor necrosis factor (TNF)-α agents represent an effective treatment for chronic inflammatory diseases. However, some concerns about their potentially undesirable effects on liver function have been reported. On the other hand, evidence of their therapeutic effects on certain liver diseases is accumulating. Many data showed the safety of anti-TNF-α in patients with chronic hepatitis B and C and in liver transplanted patients even if a strict follow-up and prophylaxis are recommended in well-defined subgroups. On the other side, anti-TNF-α-induced liver injury is not a rare event. However, it is often reversible after anti-TNF-α withdrawal. Anti-TNF-α agents have been tested in advanced stages of severe alcoholic hepatitis and non-alcoholic fatty liver disease. Limited data on the efficacy of anti-TNF-α in patients with autoimmune hepatitis and primary biliary cholangitis are also available. In this review, we explored the hepatic safety concerns in patients receiving anti-TNF-α agents with and without pre-existent hepatic diseases. In addition, the available evidence on their potential benefits in the treatment of specific hepatic diseases is discussed.
Lingua originaleEnglish
pagine (da-a)2199-N/A
RivistaInternational Journal of Molecular Sciences
Stato di pubblicazionePubblicato - 2018


  • Adalimumab
  • Alcoholic hepatitis
  • Animals
  • Autoimmune hepatitis
  • Catalysis
  • Certolizumab pegol
  • Chemical and Drug Induced Liver Injury
  • Chronic Disease
  • Computer Science Applications1707 Computer Vision and Pattern Recognition
  • Drug-induced liver injury
  • Etanercept
  • Golimumab
  • Hepatitis B virus
  • Hepatitis C virus
  • Hepatitis, Alcoholic
  • Humans
  • Inflammation
  • Infliximab
  • Inorganic Chemistry
  • Liver
  • Molecular Biology
  • Non-alcoholic Fatty Liver Disease
  • Non-alcoholic fatty liver disease
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Spectroscopy
  • Tumor Necrosis Factor-alpha


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