Gut microbiota in monozygotic twins discordant for Parkinson's disease

Carlotta Bolliri, Alessandra Fontana, Emanuele Cereda, Michela Barichella, Roberto Cilia, Valentina Ferri, Serena Caronni, Lorenzo Morelli, Gianni Pezzoli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Differences in gut microbiota between Parkinson's disease (PD) patients and controls seem to depend on multiple – frequently unmeasured – confounders. Monozygotic twins offer a unique model for controlling several factors responsible for interpersonal variation in gut microbiota. Fecal samples from 20 monozygotic twin pairs (N=40) discordant for PD were studied (metagenomic shotgun analysis). Paired-data analysis detected minimal differences in bacterial taxa abundance at species level (Bacteroides pectinophilus [P=0.037], Bifidobacterium pseudocatenulatum [P=0.050] and Bifidobacterium catenulatum [P=0.025]) and in predicted metabolic pathways (primary bile acid biosynthesis [P=0.037]). Additional studies are warranted to understand the role of gut microbiota in the pathogenesis of PD.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaAnnals of Neurology
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • Gut microbiota
  • Monozygotic twins
  • Parkinson's disease

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