Abstract
Colorectal cancer (CRC) is a worldwide public health issue specifically in patients with chronic diseases associated with a western lifestyle, such as metabolic diseases and inflammatory bowel diseases (IBD). Interestingly, both metabolic disorders and IBD are characterized by a chronic state of inflammation that contributes to the carcinogenesis with specific alteration of the gut microbiota composition and function. Evidence now shows that this altered gut microbiota contributes fueling a chronic pro-inflammatory state in a vicious circle that can favor CRC development. In this review article, we present the current knowledge concerning the involvement of the gut microbiota as a procarcinogenic factor shared by IBD and cardiometabolic diseases, and provide clues as to how it may be used to prevent or diagnose CRC.
| Lingua originale | Inglese |
|---|---|
| pagine (da-a) | N/A-N/A |
| Rivista | Best Practice and Research: Clinical Gastroenterology |
| Volume | 72 |
| Numero di pubblicazione | N/A |
| DOI | |
| Stato di pubblicazione | Pubblicato - 2024 |
OSS delle Nazioni Unite
Questo processo contribuisce al raggiungimento dei seguenti obiettivi di sviluppo sostenibile
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SDG 3 Salute e benessere
All Science Journal Classification (ASJC) codes
- Gastroenterologia
Keywords
- Chronic inflammation
- Colitis-associated cancer
- Colorectal cancer
- Gut microbiota
- Inflammatory bowel disease
- Obesity
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