TY - JOUR
T1 - Gut Microbiota and Clostridium difficile: What We Know and the New Frontiers
AU - Piccioni, Andrea
AU - Rosa, Federico
AU - Manca, Federica
AU - Pignataro, Giulia
AU - Zanza, Christian
AU - Savioli, Gabriele
AU - Covino, Marcello
AU - Ojetti, Veronica
AU - Gasbarrini, Antonio
AU - Franceschi, Francesco
PY - 2022
Y1 - 2022
N2 - : Our digestive system, particularly our intestines, harbors a vast amount of microorganisms, whose genetic makeup is referred to as the microbiome. Clostridium difficile is a spore-forming Gram-positive bacterium, which can cause an infection whose symptoms range from asymptomatic colonization to fearsome complications such as the onset of toxic megacolon. The relationship between gut microbiota and Clostridium difficile infection has been studied from different perspectives. One of the proposed strategies is to be able to specifically identify which types of microbiota alterations are most at risk for the onset of CDI. In this article, we understood once again how crucial the role of the human microbiota is in health and especially how crucial it becomes, in the case of its alteration, for the individual's disease. Clostridium difficile infection is an emblematic example of how a normal and physiological composition of the human microbiome can play a very important role in immune defense against such a fearsome disease.
AB - : Our digestive system, particularly our intestines, harbors a vast amount of microorganisms, whose genetic makeup is referred to as the microbiome. Clostridium difficile is a spore-forming Gram-positive bacterium, which can cause an infection whose symptoms range from asymptomatic colonization to fearsome complications such as the onset of toxic megacolon. The relationship between gut microbiota and Clostridium difficile infection has been studied from different perspectives. One of the proposed strategies is to be able to specifically identify which types of microbiota alterations are most at risk for the onset of CDI. In this article, we understood once again how crucial the role of the human microbiota is in health and especially how crucial it becomes, in the case of its alteration, for the individual's disease. Clostridium difficile infection is an emblematic example of how a normal and physiological composition of the human microbiome can play a very important role in immune defense against such a fearsome disease.
KW - Clostridium difficile infection
KW - gut microbiota
KW - microbiome
KW - Clostridium difficile infection
KW - gut microbiota
KW - microbiome
UR - https://publicatt.unicatt.it/handle/10807/226550
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85141551126&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85141551126&origin=inward
U2 - 10.3390/ijms232113323
DO - 10.3390/ijms232113323
M3 - Article
SN - 1422-0067
VL - 23
SP - 13323-N/A
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 21
ER -