Gut Microbiota: A Key Modulator of Intestinal Healing in Inflammatory Bowel Disease

Alfredo Papa, Antonio Gasbarrini, Loris Riccardo Lopetuso, Valentina Petito, Antonio Angelo Dal Lago, Franco Scaldaferri

Risultato della ricerca: Contributo in rivistaArticolo in rivista

14 Citazioni (Scopus)

Abstract

Mucosal healing (MH) represents a crucial factor for maintaining gut homeostasis. Indeed, in inflammatory bowel disease, MH has become the standard therapeutical target, because it is associated with more effective disease control, more frequent steroid-free remission, lower rates of hospitalization and surgery, and improved quality of life. In this scenario, gut microbiota is a crucial player in modulating intestinal repair and regeneration process. It can act on the tumor necrosis factor-α production, modulation of reactive oxygen and nitrogen species, activity of matrix metalloproteinases and on many other mechanisms strictly involved in restoring gut health. In this review, we analyze and review the literature on the role of gut microbiota in sustaining mucosal injury and achieving MH.
Lingua originaleEnglish
pagine (da-a)202-209
Numero di pagine8
RivistaDigestive Diseases
Volume34
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Bacteria
  • Gastroenterology
  • Gastrointestinal Microbiome
  • Gut microbiota
  • Humans
  • Inflammatory Bowel Diseases
  • Inflammatory bowel disease
  • Intestinal Mucosa
  • Intestines
  • Mucosal healing
  • Mucosal injury
  • Wound Healing

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