TY - JOUR
T1 - Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery
AU - D'Amario, Domenico
AU - Leone, Antonio Maria
AU - Iaconelli, Antonio
AU - Luciani, Nicola
AU - Gaudino, Mario Fulvio Luigi
AU - Kannappan, Ramaswamy
AU - Manchi, Melissa
AU - Severino, Anna
AU - Shin, Sang Hun
AU - Graziani, Francesca
AU - Biasillo, Gina
AU - Macchione, Andrea
AU - Smaldone, Costantino
AU - De Maria, Giovanni Luigi
AU - Cellini, Carlo
AU - Siracusano, Andrea
AU - Ottaviani, Lara
AU - Massetti, Massimo
AU - Goichberg, Polina
AU - Leri, Annarosa
AU - Anversa, Piero
AU - Crea, Filippo
PY - 2014
Y1 - 2014
N2 - The efficacy of bypass surgery in patients with ischemic cardiomyopathy is not easily predictable; preoperative clinical conditions may be similar, but the outcome may differ significantly. We hypothesized that the growth reserve of cardiac stem cells (CSCs) and circulating cytokines promoting CSC activation are critical determinants of ventricular remodeling in this patient population.
AB - The efficacy of bypass surgery in patients with ischemic cardiomyopathy is not easily predictable; preoperative clinical conditions may be similar, but the outcome may differ significantly. We hypothesized that the growth reserve of cardiac stem cells (CSCs) and circulating cytokines promoting CSC activation are critical determinants of ventricular remodeling in this patient population.
KW - coronary artery disease
KW - receptor, IGF type 1
KW - stem cells
KW - telomerase
KW - telomere
KW - ventricular remodeling
KW - coronary artery disease
KW - receptor, IGF type 1
KW - stem cells
KW - telomerase
KW - telomere
KW - ventricular remodeling
UR - http://hdl.handle.net/10807/52048
U2 - 10.1161/CIRCULATIONAHA.113.006591
DO - 10.1161/CIRCULATIONAHA.113.006591
M3 - Article
SN - 1524-4539
VL - 129
SP - 157
EP - 172
JO - Circulation
JF - Circulation
ER -