Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery

Nicola Luciani, Mario Fulvio Luigi Gaudino, Massimo Massetti, Filippo Crea, Domenico D'Amario, Antonio Maria Leone, Melissa Manchi, Anna Severino, Francesca Graziani, Gina Biasillo, Andrea Macchione, Costantino Smaldone, Giovanni Luigi De Maria, Carlo Cellini, Ramaswamy Kannappan, Sang Hun Shin, Polina Goichberg, Annarosa Leri, Piero Anversa

Risultato della ricerca: Contributo in rivistaArticolo in rivista

24 Citazioni (Scopus)

Abstract

The efficacy of bypass surgery in patients with ischemic cardiomyopathy is not easily predictable; preoperative clinical conditions may be similar, but the outcome may differ significantly. We hypothesized that the growth reserve of cardiac stem cells (CSCs) and circulating cytokines promoting CSC activation are critical determinants of ventricular remodeling in this patient population.
Lingua originaleEnglish
pagine (da-a)157-172
Numero di pagine16
RivistaCirculation
Volume129
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • coronary artery disease
  • receptor, IGF type 1
  • stem cells
  • telomerase
  • telomere
  • ventricular remodeling

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