Growth hormone receptor polymorphism and the effects of pegvisomant in acromegaly.

Eleonora Gaetani, Giovanni Pecorini, Alfredo Pontecorvi, Antonio Bianchi, Laura Tilaro, Flora Veltri, Laura De Marinis Grasso, G Mazziotti, Vincenzo Cimino, A Giustina

Risultato della ricerca: Contributo in rivistaArticolo in rivista

34 Citazioni (Scopus)

Abstract

BACKGROUND: Sensitivity to pegvisomant therapy is highly variable in patients with acromegaly but determinants of this variability are still unknown. Lack of exon 3 (d3-) of the growth hormone (GH) receptor (GHR) has been associated with increased biological activity of GH. OBJECTIVE: To assess whether the presence of d3-GHR haplotype may have a role in predicting dose regimen and response to pegvisomant in acromegaly. DESIGN: Case series. Setting Institutional referral center at a tertiary care hospital. Patients Nineteen acromegalic patients with active disease after unsuccessful neurosurgery and somatostatin analog therapy. MEASUREMENTS: Before and 1, 3, 6 and 12 months after treatment with pegvisomant, IGF-I; GH receptor genotype, determined from peripheral blood by polymerase chain reaction. All patients started treatment with pegvisomant at 10 mg/daily and then increased the dose, according to a fixed schedule, during a 12-month follow-up until normalization of IGF-I levels. RESULTS: d3-GHR patients required a significant lower dose of pegvisomant and shorter treatment time to normalize IGF-I. CONCLUSION: The GHR genotype could be useful in predicting dose and individual response to pegvisomant in acromegaly.
Lingua originaleEnglish
pagine (da-a)196-199
Numero di pagine4
RivistaPituitary
Volume2009
Stato di pubblicazionePubblicato - 2009

Keywords

  • Acromegaly

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