Abstract

Aim: Fabrication of graphene oxide (GO)-based medical devices coatings that limit adhesion of Candida albicans, a main issue of healthcare-associated infections. Methods: The GO composites noncovalently functionalized with curcumin (CU), a hydrophobic molecule with active antimicrobial action, polyethylene glycol (PEG) that hinders the absorption of biomolecules or a combination of CU and PEG (GO-CU-PEG) were drop-casted on surfaces and antifungal efficacy was assessed. Results: We demonstrate that GO-CU-PEG coatings can reduce fungal adhesion, proliferation and biofilm formation. Furthermore, in an aqueous environment, surfaces release curcumin-PEG nanocomposites that have a minimum inhibitory concentration of 9.25 μg/ml against C. albicans. Conclusion: Prevention of early cell adhesion and creation of a proximal environment unfavorable for growth make these GO-supported biomaterials attractive for innovative medical device manufacturing.
Lingua originaleEnglish
pagine (da-a)2867-2879
Numero di pagine13
RivistaNanomedicine
Volume13
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Bioengineering
  • Biomedical Engineering
  • Materials Science (all)
  • Medicine (miscellaneous)
  • PEGylation
  • coating
  • curcumin
  • graphene
  • immunology/infectious diseases
  • nanocomposites
  • preventive medicine
  • targeted therapy

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