Graft steatosis as a risk factor of ischemic-type biliary lesions in liver transplantation

Gabriele Sganga, Alfonso Wolfango Avolio, Salvatore Agnes, Francesco Frongillo, Maria Carmen Lirosi, Ugo Grossi, Erida Nure, Giuseppe Bianco

Risultato della ricerca: Contributo in rivistaArticolo in rivista

8 Citazioni (Scopus)

Abstract

Ischemic-type biliary lesions (ITBLs) are now a discussed cause of morbidity and mortality in liver transplant recipients, even if not definitively characterized. We reviewed 13 years of donor and recipient data between April 2001 and April 2013. We evaluated the incidence of ITBL occurrence, exploring the possible predisposing factors, focusing on the relationship between severe macrovesicular steatosis of the graft and incidence of ITBL. A total of 445 grafts were harvested: 416 of them were transplanted at our institution, the remaining 29 were discarded by our donor team as showing more than 40% macrovesicular steatosis. Mild-moderate (20% to 40%) macrovesicular steatosis (P<.001) and cold ischemia time (P=.048) significantly increased the risk of ITBLs, also resulting in independent risk factors at multivariate analysis.
Lingua originaleEnglish
pagine (da-a)2293-2294
Numero di pagine2
RivistaTransplantation Proceedings
Volume46
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • liver transplantation

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