Gonadal Function after Busulfan Compared with Treosulfan in Children and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplant

Maura Faraci; Tamara Diesch; Myriam Labopin; Arnaud Dalissier; Arian Lankester; Andrew Gennery; Mikael Sundin; Duygu Uckan-Cetinkaya; Marc Bierings; Anke M.J. Peters; Martina Garwer; Ansgar Schulz; Gerard Michel; Giovanna Giorgiani; Bernd Gruhn; Franco Locatelli; Stefano Giardino; Anne Uyttebroeck; Fanny Rialland; Maija Itäla-Remes; Peter Dreger; Peter J. Shaw; Victoria Bordon; Paul G. Schlegel; Karin Mellgren; Jose M. Moraleda; Katharine Patrick; Pascale Schneider; Charlotte Jubert; Anita Lawitschka; Nina Salooja; Grzegorz W. Basak; Selim Corbacioglu; Rafael Duarte; Peter Bader

doi:10.1016/j.bbmt.2019.05.005

Gonadal Function after Busulfan Compared with Treosulfan in Children and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplant

Maura Faraci, Tamara Diesch, Myriam Labopin, Arnaud Dalissier, Arian Lankester, Andrew Gennery, Mikael Sundin, Duygu Uckan-Cetinkaya, Marc Bierings, Anke M.J. Peters, Martina Garwer, Ansgar Schulz, Gerard Michel, Giovanna Giorgiani, Bernd Gruhn, Franco Locatelli, Stefano Giardino, Anne Uyttebroeck, Fanny Rialland, Maija Itäla-RemesPeter Dreger, Peter J. Shaw, Victoria Bordon, Paul G. Schlegel, Karin Mellgren, Jose M. Moraleda, Katharine Patrick, Pascale Schneider, Charlotte Jubert, Anita Lawitschka, Nina Salooja, Grzegorz W. Basak, Selim Corbacioglu, Rafael Duarte, Peter Bader

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Gonadal impairment is an important late effect with a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after busulfan (Bu) or treosulfan (Treo) conditioning regimens in pre- and postpubertal children. This retrospective, multicenter study included children transplanted in pediatric European Society for Blood and Marrow Transplantation (EBMT) centers between 1992 and 2012 who did not receive gonadotoxic chemoradiotherapy before the transplant. We evaluated 137 patients transplanted in 25 pediatric EBMT centers. Median age at transplant was 11.04 years (range, 5 to 18); 89 patients were boys and 48 girls. Eighty-nine patients were prepubertal at transplant and 48 postpubertal. One hundred eighteen children received Bu and 19 Treo. A higher proportion of girls treated with Treo in the prepubertal stage reached spontaneous puberty compared with those treated with Bu (P = .02). Spontaneous menarche was more frequent after Treo than after Bu (P < .001). Postpubertal boys and girls treated with Treo had significantly lower luteinizing hormone levels (P = .03 and P = .04, respectively) compared with the Bu group. Frequency of gonadal damage associated with Treo was significantly lower than that observed after Bu. These results need to be confirmed in a larger population.

Lingua originale	English
pagine (da-a)	1786-1791
Numero di pagine	6
Rivista	Biology of Blood and Marrow Transplantation
Volume	25
DOI	https://doi.org/10.1016/j.bbmt.2019.05.005
Stato di pubblicazione	Pubblicato - 2019

Keywords

Busulfan
Gonadal damage
Pubertal stage
Treosulfan

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10.1016/j.bbmt.2019.05.005

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Faraci, M., Diesch, T., Labopin, M., Dalissier, A., Lankester, A., Gennery, A., Sundin, M., Uckan-Cetinkaya, D., Bierings, M., Peters, A. M. J., Garwer, M., Schulz, A., Michel, G., Giorgiani, G., Gruhn, B., Locatelli, F., Giardino, S., Uyttebroeck, A., Rialland, F., ... Bader, P. (2019). Gonadal Function after Busulfan Compared with Treosulfan in Children and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplant. Biology of Blood and Marrow Transplantation, 25, 1786-1791. https://doi.org/10.1016/j.bbmt.2019.05.005

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title = "Gonadal Function after Busulfan Compared with Treosulfan in Children and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplant",

abstract = "Gonadal impairment is an important late effect with a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after busulfan (Bu) or treosulfan (Treo) conditioning regimens in pre- and postpubertal children. This retrospective, multicenter study included children transplanted in pediatric European Society for Blood and Marrow Transplantation (EBMT) centers between 1992 and 2012 who did not receive gonadotoxic chemoradiotherapy before the transplant. We evaluated 137 patients transplanted in 25 pediatric EBMT centers. Median age at transplant was 11.04 years (range, 5 to 18); 89 patients were boys and 48 girls. Eighty-nine patients were prepubertal at transplant and 48 postpubertal. One hundred eighteen children received Bu and 19 Treo. A higher proportion of girls treated with Treo in the prepubertal stage reached spontaneous puberty compared with those treated with Bu (P = .02). Spontaneous menarche was more frequent after Treo than after Bu (P < .001). Postpubertal boys and girls treated with Treo had significantly lower luteinizing hormone levels (P = .03 and P = .04, respectively) compared with the Bu group. Frequency of gonadal damage associated with Treo was significantly lower than that observed after Bu. These results need to be confirmed in a larger population.",

keywords = "Busulfan, Gonadal damage, Pubertal stage, Treosulfan, Busulfan, Gonadal damage, Pubertal stage, Treosulfan",

author = "Maura Faraci and Tamara Diesch and Myriam Labopin and Arnaud Dalissier and Arian Lankester and Andrew Gennery and Mikael Sundin and Duygu Uckan-Cetinkaya and Marc Bierings and Peters, {Anke M.J.} and Martina Garwer and Ansgar Schulz and Gerard Michel and Giovanna Giorgiani and Bernd Gruhn and Franco Locatelli and Stefano Giardino and Anne Uyttebroeck and Fanny Rialland and Maija It{\"a}la-Remes and Peter Dreger and Shaw, {Peter J.} and Victoria Bordon and Schlegel, {Paul G.} and Karin Mellgren and Moraleda, {Jose M.} and Katharine Patrick and Pascale Schneider and Charlotte Jubert and Anita Lawitschka and Nina Salooja and Basak, {Grzegorz W.} and Selim Corbacioglu and Rafael Duarte and Peter Bader",

year = "2019",

doi = "10.1016/j.bbmt.2019.05.005",

language = "English",

volume = "25",

pages = "1786--1791",

journal = "Biology of Blood and Marrow Transplantation",

issn = "1083-8791",

publisher = "-NEW YORK:ELSEVIER SCIENCE INC -Charlottesville, VA : Carden Jennings Publishing -Charlottesville, VA : Kluge Carden Jennings Pub. Co., [1995-",

}

Faraci, M, Diesch, T, Labopin, M, Dalissier, A, Lankester, A, Gennery, A, Sundin, M, Uckan-Cetinkaya, D, Bierings, M, Peters, AMJ, Garwer, M, Schulz, A, Michel, G, Giorgiani, G, Gruhn, B, Locatelli, F, Giardino, S, Uyttebroeck, A, Rialland, F, Itäla-Remes, M, Dreger, P, Shaw, PJ, Bordon, V, Schlegel, PG, Mellgren, K, Moraleda, JM, Patrick, K, Schneider, P, Jubert, C, Lawitschka, A, Salooja, N, Basak, GW, Corbacioglu, S, Duarte, R & Bader, P 2019, 'Gonadal Function after Busulfan Compared with Treosulfan in Children and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplant', Biology of Blood and Marrow Transplantation, vol. 25, pagg. 1786-1791. https://doi.org/10.1016/j.bbmt.2019.05.005

TY - JOUR

T1 - Gonadal Function after Busulfan Compared with Treosulfan in Children and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplant

AU - Faraci, Maura

AU - Diesch, Tamara

AU - Labopin, Myriam

AU - Dalissier, Arnaud

AU - Lankester, Arian

AU - Gennery, Andrew

AU - Sundin, Mikael

AU - Uckan-Cetinkaya, Duygu

AU - Bierings, Marc

AU - Peters, Anke M.J.

AU - Garwer, Martina

AU - Schulz, Ansgar

AU - Michel, Gerard

AU - Giorgiani, Giovanna

AU - Gruhn, Bernd

AU - Locatelli, Franco

AU - Giardino, Stefano

AU - Uyttebroeck, Anne

AU - Rialland, Fanny

AU - Itäla-Remes, Maija

AU - Dreger, Peter

AU - Shaw, Peter J.

AU - Bordon, Victoria

AU - Schlegel, Paul G.

AU - Mellgren, Karin

AU - Moraleda, Jose M.

AU - Patrick, Katharine

AU - Schneider, Pascale

AU - Jubert, Charlotte

AU - Lawitschka, Anita

AU - Salooja, Nina

AU - Basak, Grzegorz W.

AU - Corbacioglu, Selim

AU - Duarte, Rafael

AU - Bader, Peter

PY - 2019

Y1 - 2019

N2 - Gonadal impairment is an important late effect with a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after busulfan (Bu) or treosulfan (Treo) conditioning regimens in pre- and postpubertal children. This retrospective, multicenter study included children transplanted in pediatric European Society for Blood and Marrow Transplantation (EBMT) centers between 1992 and 2012 who did not receive gonadotoxic chemoradiotherapy before the transplant. We evaluated 137 patients transplanted in 25 pediatric EBMT centers. Median age at transplant was 11.04 years (range, 5 to 18); 89 patients were boys and 48 girls. Eighty-nine patients were prepubertal at transplant and 48 postpubertal. One hundred eighteen children received Bu and 19 Treo. A higher proportion of girls treated with Treo in the prepubertal stage reached spontaneous puberty compared with those treated with Bu (P = .02). Spontaneous menarche was more frequent after Treo than after Bu (P < .001). Postpubertal boys and girls treated with Treo had significantly lower luteinizing hormone levels (P = .03 and P = .04, respectively) compared with the Bu group. Frequency of gonadal damage associated with Treo was significantly lower than that observed after Bu. These results need to be confirmed in a larger population.

AB - Gonadal impairment is an important late effect with a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after busulfan (Bu) or treosulfan (Treo) conditioning regimens in pre- and postpubertal children. This retrospective, multicenter study included children transplanted in pediatric European Society for Blood and Marrow Transplantation (EBMT) centers between 1992 and 2012 who did not receive gonadotoxic chemoradiotherapy before the transplant. We evaluated 137 patients transplanted in 25 pediatric EBMT centers. Median age at transplant was 11.04 years (range, 5 to 18); 89 patients were boys and 48 girls. Eighty-nine patients were prepubertal at transplant and 48 postpubertal. One hundred eighteen children received Bu and 19 Treo. A higher proportion of girls treated with Treo in the prepubertal stage reached spontaneous puberty compared with those treated with Bu (P = .02). Spontaneous menarche was more frequent after Treo than after Bu (P < .001). Postpubertal boys and girls treated with Treo had significantly lower luteinizing hormone levels (P = .03 and P = .04, respectively) compared with the Bu group. Frequency of gonadal damage associated with Treo was significantly lower than that observed after Bu. These results need to be confirmed in a larger population.

KW - Busulfan

KW - Gonadal damage

KW - Pubertal stage

KW - Treosulfan

KW - Busulfan

KW - Gonadal damage

KW - Pubertal stage

KW - Treosulfan

UR - http://hdl.handle.net/10807/229125

U2 - 10.1016/j.bbmt.2019.05.005

DO - 10.1016/j.bbmt.2019.05.005

M3 - Article

SN - 1083-8791

VL - 25

SP - 1786

EP - 1791

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

ER -

Gonadal Function after Busulfan Compared with Treosulfan in Children and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplant

Abstract

Keywords

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