GnRH analogue treatment before hysteroscopic resection of submucous myomas: A prospective, randomized, multicenter study

L Muzii, T Boni, F Bellati, Riccardo Marana, A Ruggiero, M Zullo, R Angioli, P. B. Panici

Risultato della ricerca: Contributo in rivistaArticolo in rivista

56 Citazioni (Scopus)


Objective: To evaluate the efficacy of GnRH analogue treatment before hysteroscopic resection of submucous myomas in patients with abnormal uterine bleeding. Design: Multicenter, prospective, randomized, clinical study. Setting: Tertiary-care university hospitals. Patient(s): Thirty-nine consecutive patients with submucous myomas graded as G0 or G1 according to the European Society for Gynecological Endoscopy classification (myoma size 10-35 mm). Intervention(s): Patients were randomized to either direct surgery or 2 months of GnRH analogues before undergoing hysteroscopic resection of the submucous myoma. Main Outcome Measure(s): Operating times, fluid absorption, difficulty of the operation, surgeon satisfaction with the procedure, intra- and postoperative complications, postoperative pain, and patient satisfaction were recorded. Result(s): Patients treated with GnRH analogue had significantly shorter operative times (15.9 ± 3.1 minutes vs. 21.3 ± 4.0 minutes) and significantly reduced fluid absorption (378 ± 137 mL vs. 566 ± 199 mL) compared with no preoperative medical treatment. Operative difficulty and overall surgeon satisfaction were significantly better in the GnRH analogue group. Patient satisfaction was similar in the two groups. Conclusion(s): GnRH analogue treatment before hysteroscopic resection of G0-G1 10-35 mm submucous myomas was effective in reducing operative times, fluid absorption, and difficulty of the procedure. Copyright © 2010 American Society for Reproductive Medicine, Published by Elsevier Inc.
Lingua originaleEnglish
pagine (da-a)1496-1499
Numero di pagine4
RivistaFertility and Sterility
Stato di pubblicazionePubblicato - 2010
Pubblicato esternamente


  • Algorithms
  • Antineoplastic Agents, Hormonal
  • Combined Modality Therapy
  • Drug Administration Schedule
  • Female
  • Gonadotropin-Releasing Hormone
  • Humans
  • Hysteroscopy
  • Leiomyoma
  • Luteolytic Agents
  • Middle Aged
  • Mucous Membrane
  • Neoadjuvant Therapy
  • Postoperative Complications
  • Triptorelin
  • Uterine Hemorrhage
  • Uterine Neoplasms
  • amenorrhea
  • article
  • cancer classification
  • cancer grading
  • clinical article
  • clinical trial
  • comparative study
  • controlled clinical trial
  • controlled study
  • drug efficacy
  • female
  • hot flush
  • human
  • hysteroscopy
  • multicenter study
  • myoma
  • operation duration
  • patient satisfaction
  • peroperative complication
  • postoperative complication
  • postoperative pain
  • priority journal
  • prospective study
  • randomized controlled trial
  • surgical technique
  • tertiary health care
  • triptorelin, adult
  • tumor volume
  • university hospital
  • uterus bleeding, Adult


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