GLUT 1 receptor expression and circulating levels of fasting glucose in high grade serous ovarian cancer

Ruggero De Maria Marchiano, Giacomo Corrado, Paolo Marchetti, Laura Pizzuti, Domenico Sergi, Chiara Mandoj, Barbara Antoniani, Francesca Sperati, Andrea Chirico, Luigi Di Lauro, Mario Valle, Alfredo Garofalo, Enrico Vizza, Federica Tomao, Massimo Rinaldi, Silvia Carpano, Marcello Maugeri-Saccà, Laura Conti, Giovanna Digiesi, Antonio GiordanoMaddalena Barba, Maria A. Carosi, Patrizia Vici

Risultato della ricerca: Contributo in rivistaArticolo in rivista

11 Citazioni (Scopus)

Abstract

In recent years, the poorly remarkable goals achieved in terms of patients’ important outcomes for ovarian cancer have fueled our interest toward the study of its metabolic roots. Within this research pipeline, we assessed the association between the expression of the glucose transporter GLUT1, as expressed at the tumor tissue level, and circulating pre-surgical levels of fasting glucose in a case series including data from 40 patients with high FIGO stage serous ovarian cancer. Patients who provided data to the current analysis were randomly selected from a larger cohort. To our purposes, the procedures related to serum and tissue collection, storage and biomarker assessment were highly standardized and centralized at the institutional laboratories. The GLUT1 antibody SPM498 SPRING (REF. E13810) was used at a 1:500 dilution in 2 µm slides. Staining for GLUT1 was observed at the cell membrane level in all the cases assessed, but strong staining was described in 29 (72.5%) of them. The agreement between the two independent reviewers was 100%. Strong GLUT1 staining was inversely associated with circulating levels of fasting glucose, with a particularly striking difference for patients in the lowest fasting glucose tertile (p = 0.044). These results support the biological plausibility of the association of interest. If confirmed in larger studies, our findings may help clarify the potentials of biomarkers related to energy metabolism in terms of prognosis definition, treatment assignment, and outcome interpretation for patients with high FIGO stage serous ovarian cancer.
Lingua originaleEnglish
pagine (da-a)1396-1401
Numero di pagine6
RivistaJournal of Cellular Physiology
Volume233
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Adult
  • Aged
  • Biomarkers, Tumor
  • Biopsy
  • Blood Glucose
  • Cell Biology
  • Clinical Biochemistry
  • Cystadenocarcinoma, Serous
  • Fasting
  • Female
  • GLUT1
  • Glucose Transporter Type 1
  • Humans
  • Immunohistochemistry
  • Medicine (all)
  • Middle Aged
  • Neoplasm Grading
  • Observer Variation
  • Ovarian Neoplasms
  • Physiology
  • Reproducibility of Results
  • fasting glucose
  • ovarian cancer
  • serous high FIGO stage

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