Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment

Andrea Giaccari; Gianpio Sorice; Giovanna Muscogiuri

doi:10.1016/j.numecd.2009.03.018

Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment

Andrea Giaccari
, Gianpio Sorice
, Giovanna Muscogiuri

Risultato della ricerca: Contributo in rivista › Articolo › peer review

77 Citazioni (Scopus)

Abstract

Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.

Lingua originale	Inglese
pagine (da-a)	365-377
Numero di pagine	13
Rivista	NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume	19
DOI	https://doi.org/10.1016/j.numecd.2009.03.018
Stato di pubblicazione	Pubblicato - 2009

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Keywords

Blood Glucose
Cardiovascular Diseases
Diabetes Complications
Diabetes Mellitus, Type 2
Hexosamines
Humans
Hyperglycemia
Hypoglycemic Agents
Insulin
Oxidative Stress
Protein Kinase C
Secondary Prevention

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10.1016/j.numecd.2009.03.018

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title = "Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment",

abstract = "Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.",

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author = "Andrea Giaccari and Gianpio Sorice and Giovanna Muscogiuri",

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AU - Sorice, Gianpio

AU - Muscogiuri, Giovanna

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N2 - Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.

AB - Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.

KW - Blood Glucose

KW - Cardiovascular Diseases

KW - Diabetes Complications

KW - Diabetes Mellitus, Type 2

KW - Hexosamines

KW - Humans

KW - Hyperglycemia

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KW - Oxidative Stress

KW - Protein Kinase C

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KW - Cardiovascular Diseases

KW - Diabetes Complications

KW - Diabetes Mellitus, Type 2

KW - Hexosamines

KW - Humans

KW - Hyperglycemia

KW - Hypoglycemic Agents

KW - Insulin

KW - Oxidative Stress

KW - Protein Kinase C

KW - Secondary Prevention

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M3 - Article

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JO - NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

JF - NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

ER -

Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment

Abstract

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Keywords

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