Glucose toxicity: the leading actor in the pathogenesis and clinical history of type 2 diabetes - mechanisms and potentials for treatment

Andrea Giaccari, Gianpio Sorice, Giovanna Muscogiuri

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

77 Citazioni (Scopus)

Abstract

Although it is now well established that the deleterious effects of chronic hyperglycaemia (i.e., glucose toxicity) play an important role in the progressive impairment of insulin secretion and sensitivity, the two major actors of the pathogenesis of type 2 diabetes mellitus, the precise biochemical and molecular mechanisms responsible for the defects induced by glucose toxicity still remain to be defined.
Lingua originaleEnglish
pagine (da-a)365-377
Numero di pagine13
RivistaNMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume19
DOI
Stato di pubblicazionePubblicato - 2009

Keywords

  • Blood Glucose
  • Cardiovascular Diseases
  • Diabetes Complications
  • Diabetes Mellitus, Type 2
  • Hexosamines
  • Humans
  • Hyperglycemia
  • Hypoglycemic Agents
  • Insulin
  • Oxidative Stress
  • Protein Kinase C
  • Secondary Prevention

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