Glucose-induced thermogenesis in postobese women who have undergone biliopancreatic diversion

Geltrude Mingrone, Esmeralda Capristo, Paolo Caradonna, Andrea De Gaetano, Marco Castagneto, Pa Tataranni, Av Greco, Ca Raguso, Rm Tacchino

Risultato della ricerca: Contributo in rivistaArticolo in rivista

30 Citazioni (Scopus)

Abstract

We evaluated the metabolic response to a standard (75-g) oral-glucose-tolerance test (OGTT) in eight post-obese women (PO) who underwent biliopancreatic diversion and in eight healthy control women (C). All subjects had been weight-stable for > or = 2 y. Blood samples for glucose, insulin, C-peptide, and nonesterified free fatty acids were taken at baseline and during 180 min after the glucose load. Plasma glucose and insulin concentrations at baseline and during the OGTT were similar in the two groups, suggesting the absence of an insulin-resistant state in the PO. Continuous indirect calorimetry was performed throughout the test. Glucose-induced thermogenesis (GIT) was higher in PO than in C (8.6 +/- 2.6 vs 4.3 +/- 1.9%; P < 0.01). These data indicate that GIT and insulin-glucose metabolism are not impaired in postobese patients when a near ideal body weight is reached and maintained after weight loss; this suggests that thermogenic deficiencies and hyperinsulinemia-insulin resistance are alterations secondary to obesity.
Lingua originaleEnglish
pagine (da-a)320-326
Numero di pagine7
RivistaTHE AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume60
Stato di pubblicazionePubblicato - 1994

Keywords

  • Adult
  • Biliopancreatic Diversion
  • Blood Glucose
  • C-Peptide
  • Calorimetry, Indirect
  • Energy Intake
  • Energy Metabolism
  • Fatty Acids, Nonesterified
  • Female
  • Glucose
  • Glucose Tolerance Test
  • Humans
  • Insulin
  • Lipid Metabolism
  • Obesity, Morbid
  • Oxidation-Reduction
  • Postoperative Period

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