Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease

S Petta; Luca Miele; E Bugianesi; C Cammà; C Rosso; Stefania Boccia; D Cabibi; V Di Marco; S Grimaudo; Antonio Grieco; Rm Pipitone; G Marchesini; A. Craxì

doi:10.1371/journal.pone.0087523

Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease

S Petta
, Luca Miele
, E Bugianesi
, C Cammà
, C Rosso
, Stefania Boccia
, D Cabibi
, V Di Marco
, S Grimaudo
, Antonio Grieco
, Rm Pipitone
, G Marchesini
, A. Craxì

Risultato della ricerca: Contributo in rivista › Articolo

79 Citazioni (Scopus)

Abstract

Variant in glucokinase regulatory protein (GCKR), associated with lipid and glucose traits, has been suggested to affect fatty liver infiltration. We aimed to assess whether GCKR rs780094 C→T SNP influences the expression of steatosis, lobular inflammation and fibrosis in NAFLD patients, after correction for PNPLA3 genotype.

Lingua originale	Inglese
pagine (da-a)	e87523-e87523
Rivista	PLoS One
Volume	9
Numero di pubblicazione	2
DOI	https://doi.org/10.1371/journal.pone.0087523
Stato di pubblicazione	Pubblicato - 2014

All Science Journal Classification (ASJC) codes

Multidisciplinare

Keywords

GENETICS
GLUCKINASE
LIVER FIBROSIS
NAFLD

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10.1371/journal.pone.0087523

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abstract = "Variant in glucokinase regulatory protein (GCKR), associated with lipid and glucose traits, has been suggested to affect fatty liver infiltration. We aimed to assess whether GCKR rs780094 C→T SNP influences the expression of steatosis, lobular inflammation and fibrosis in NAFLD patients, after correction for PNPLA3 genotype.",

keywords = "GENETICS, GLUCKINASE, LIVER FIBROSIS, NAFLD, GENETICS, GLUCKINASE, LIVER FIBROSIS, NAFLD",

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T1 - Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease

AU - Petta, S

AU - Miele, Luca

AU - Bugianesi, E

AU - Cammà, C

AU - Rosso, C

AU - Boccia, Stefania

AU - Cabibi, D

AU - Di Marco, V

AU - Grimaudo, S

AU - Grieco, Antonio

AU - Pipitone, Rm

AU - Marchesini, G

AU - Craxì, A.

PY - 2014

Y1 - 2014

N2 - Variant in glucokinase regulatory protein (GCKR), associated with lipid and glucose traits, has been suggested to affect fatty liver infiltration. We aimed to assess whether GCKR rs780094 C→T SNP influences the expression of steatosis, lobular inflammation and fibrosis in NAFLD patients, after correction for PNPLA3 genotype.

AB - Variant in glucokinase regulatory protein (GCKR), associated with lipid and glucose traits, has been suggested to affect fatty liver infiltration. We aimed to assess whether GCKR rs780094 C→T SNP influences the expression of steatosis, lobular inflammation and fibrosis in NAFLD patients, after correction for PNPLA3 genotype.

KW - GENETICS

KW - GLUCKINASE

KW - LIVER FIBROSIS

KW - NAFLD

KW - GENETICS

KW - GLUCKINASE

KW - LIVER FIBROSIS

KW - NAFLD

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Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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