TY - JOUR
T1 - Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae
AU - Singh, Kumar Saurabh
AU - Cordeiro, Erick M. G.
AU - Troczka, Bartlomiej J.
AU - Pym, Adam
AU - Mackisack, Joanna
AU - Mathers, Thomas C.
AU - Duarte, Ana
AU - Legeai, Fabrice
AU - Robin, Stéphanie
AU - Bielza, Pablo
AU - Burrack, Hannah J.
AU - Charaabi, Kamel
AU - Denholm, Ian
AU - Figueroa, Christian C.
AU - Ffrench-Constant, Richard H.
AU - Jander, Georg
AU - Margaritopoulos, John T.
AU - Mazzoni, Emanuele
AU - Nauen, Ralf
AU - Ramírez, Claudio C.
AU - Ren, Guangwei
AU - Stepanyan, Ilona
AU - Umina, Paul A.
AU - Voronova, Nina V.
AU - Vontas, John
AU - Williamson, Martin S.
AU - Wilson, Alex C. C.
AU - Xi-Wu, Gao
AU - Youn, Young-Nam
AU - Zimmer, Christoph T.
AU - Simon, Jean-Christophe
AU - Hayward, Alex
AU - Bass, Chris
PY - 2021
Y1 - 2021
N2 - The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host–plant associations, uncovering the widespread co‐option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites
AB - The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host–plant associations, uncovering the widespread co‐option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites
KW - Myzus persicae
KW - genome
KW - insecticide resistance
KW - Myzus persicae
KW - genome
KW - insecticide resistance
UR - http://hdl.handle.net/10807/181772
U2 - 10.1038/s42003-021-02373-x
DO - 10.1038/s42003-021-02373-x
M3 - Article
SN - 2399-3642
VL - 4
SP - N/A-N/A
JO - Communications Biology
JF - Communications Biology
ER -