Gliptin-associated bullous pemphigoid shows peculiar features of anti-BP180 and -BP230 humoral response: Results of a multicenter study

Adele Salemme, Luca Fania, Alessandra Scarabello, Marzia Caproni, Angelo Valerio Marzano, Emanuele Cozzani, Claudio Feliciani, Clara De Simone, Manuela Papini, Rosanna Rita Satta, Aurora Parodi, Feliciana Mariotti, Stefania Lechiancole, Giovanni Genovese, Francesca Passarelli, Francesca Festa, Barbara Bellei, Alessia Provini, Donatella Sordi, Sabatino PallottaDamiano Abeni, Cinzia Mazzanti, Biagio Didona, Giovanni Di Zenzo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: Recently, several case-control studies demonstrated an association between gliptins and bullous pemphigoid (BP) occurrence. However, data on the clinical and immunologic features of gliptin-associated bullous pemphigoid (GABP) are controversial. Objective: This study aimed to clinically and immunologically characterize a large cohort of GABP patients to get an insight into the pathophysiology of this emerging drug-induced variant of BP. Methods: Seventy-four GABP patients were prospectively enrolled and characterized from 9 different Italian dermatology units between 2013 and 2020. Results: Our findings demonstrated the following in the GABP patients: (1) a noninflammatory phenotype, which is characterized by low amounts of circulating and skin-infiltrating eosinophils, is frequently found; (2) immunoglobulin (Ig)G, IgE, and IgA humoral responses to BP180 and BP230 antigens are reduced in frequency and titers compared with those in patients with idiopathic BP; (3) IgG reactivity targets multiple BP180 epitopes other than noncollagenous region 16A. Limitations: A limitation of the study is that the control group did not comprise only type 2 diabetes mellitus patients with BP. Conclusion: GABP patients show peculiar features of anti-BP180 and -BP230 humoral responses, laying the foundation for diagnostic improvements and getting novel insights into understanding the mechanism of BP onset.
Lingua originaleEnglish
pagine (da-a)56-63
Numero di pagine8
RivistaJournal of the American Academy of Dermatology
Volume87
DOI
Stato di pubblicazionePubblicato - 2022

Keywords

  • BP180
  • autoantibody
  • humoral response
  • epitope
  • gliptin
  • bullous pemphigoid

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