Glioblastoma in multiple sclerosis: a case report

Giovanni Frisullo; Agata Katia Patanella; Viviana Nociti; Alessandro Cianfoni; Raffaele Iorio; Assunta Bianco; Alessandro Marti; Pietro Attilio Tonali; Anna Paola Batocchi

Glioblastoma in multiple sclerosis: a case report

Giovanni Frisullo, Agata Katia Patanella, Viviana Nociti, Alessandro Cianfoni, Raffaele Iorio, Assunta Bianco, Alessandro Marti, Pietro Attilio Tonali, Anna Paola Batocchi

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

8 Citazioni (Scopus)

Abstract

Cerebral tumor and multiple sclerosis (MS) relapses can show overlapping clinical and magnetic resonance imaging features. In a previous study we observed in relapsing MS patients increased T-bet, pSTAT1, and pSTAT3 expressions in circulating mononuclear cells. During the data analysis we observed that T-bet, pSTAT1, and pSTAT3 expression was not increased in circulating mononuclear cells from a relapsing-remitting (RR)MS patient with recent onset of new neurological signs due to glioblastoma multiforme. In conclusion, our patient represents an exemplary case which suggests that T-bet, pSTAT1, and pSTAT3 expression in peripheral blood mononuclear cells (PBMCs) might be useful to differentiate MS relapses from other noninflammatory diseases.

Lingua originale	English
pagine (da-a)	141-144
Numero di pagine	4
Rivista	Journal of Neuro-Oncology
Stato di pubblicazione	Pubblicato - 2009

Keywords

glioblastoma multiforme
multiple sclerosis

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title = "Glioblastoma in multiple sclerosis: a case report",

abstract = "Cerebral tumor and multiple sclerosis (MS) relapses can show overlapping clinical and magnetic resonance imaging features. In a previous study we observed in relapsing MS patients increased T-bet, pSTAT1, and pSTAT3 expressions in circulating mononuclear cells. During the data analysis we observed that T-bet, pSTAT1, and pSTAT3 expression was not increased in circulating mononuclear cells from a relapsing-remitting (RR)MS patient with recent onset of new neurological signs due to glioblastoma multiforme. In conclusion, our patient represents an exemplary case which suggests that T-bet, pSTAT1, and pSTAT3 expression in peripheral blood mononuclear cells (PBMCs) might be useful to differentiate MS relapses from other noninflammatory diseases.",

keywords = "glioblastoma multiforme, multiple sclerosis, glioblastoma multiforme, multiple sclerosis",

author = "Giovanni Frisullo and Patanella, {Agata Katia} and Viviana Nociti and Alessandro Cianfoni and Raffaele Iorio and Assunta Bianco and Alessandro Marti and Tonali, {Pietro Attilio} and Batocchi, {Anna Paola}",

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TY - JOUR

T1 - Glioblastoma in multiple sclerosis: a case report

AU - Frisullo, Giovanni

AU - Patanella, Agata Katia

AU - Nociti, Viviana

AU - Cianfoni, Alessandro

AU - Iorio, Raffaele

AU - Bianco, Assunta

AU - Marti, Alessandro

AU - Tonali, Pietro Attilio

AU - Batocchi, Anna Paola

PY - 2009

Y1 - 2009

N2 - Cerebral tumor and multiple sclerosis (MS) relapses can show overlapping clinical and magnetic resonance imaging features. In a previous study we observed in relapsing MS patients increased T-bet, pSTAT1, and pSTAT3 expressions in circulating mononuclear cells. During the data analysis we observed that T-bet, pSTAT1, and pSTAT3 expression was not increased in circulating mononuclear cells from a relapsing-remitting (RR)MS patient with recent onset of new neurological signs due to glioblastoma multiforme. In conclusion, our patient represents an exemplary case which suggests that T-bet, pSTAT1, and pSTAT3 expression in peripheral blood mononuclear cells (PBMCs) might be useful to differentiate MS relapses from other noninflammatory diseases.

AB - Cerebral tumor and multiple sclerosis (MS) relapses can show overlapping clinical and magnetic resonance imaging features. In a previous study we observed in relapsing MS patients increased T-bet, pSTAT1, and pSTAT3 expressions in circulating mononuclear cells. During the data analysis we observed that T-bet, pSTAT1, and pSTAT3 expression was not increased in circulating mononuclear cells from a relapsing-remitting (RR)MS patient with recent onset of new neurological signs due to glioblastoma multiforme. In conclusion, our patient represents an exemplary case which suggests that T-bet, pSTAT1, and pSTAT3 expression in peripheral blood mononuclear cells (PBMCs) might be useful to differentiate MS relapses from other noninflammatory diseases.

KW - glioblastoma multiforme

KW - multiple sclerosis

KW - glioblastoma multiforme

KW - multiple sclerosis

UR - http://hdl.handle.net/10807/19690

M3 - Article

SN - 0167-594X

SP - 141

EP - 144

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

ER -

Glioblastoma in multiple sclerosis: a case report

Abstract

Keywords

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