GH receptor isoforms and skeletal fragility in acromegaly

Alfredo Pontecorvi, Marilda Mormando, Antonio Bianchi, Antonella Giampietro, Enrico Pola, Laura De Marinis Grasso, Gherardo Mazziotti, Andrea Giustina

Risultato della ricerca: Contributo in rivistaArticolo in rivista

22 Citazioni (Scopus)

Abstract

Acromegaly is associated with an increased prevalence of vertebral fractures (VFs) in close relationship with GH hypersecretion. Two isoforms of the GH receptor (GHR) have been identified; the two isoforms differ or not by the expression of the protein fragment encoded by exon 3 of the GHR gene. Deletion of the exon 3 may influence the functional properties of the GHR and affect fracture risk in acromegalic patients.
Lingua originaleEnglish
pagine (da-a)237-245
Numero di pagine9
RivistaEuropean Journal of Endocrinology
Volume171
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Acromegaly
  • Adult
  • Aged
  • Bone Density
  • Cross-Sectional Studies
  • Exons
  • Female
  • Gene Deletion
  • Humans
  • Insulin-Like Growth Factor I
  • Italy
  • Male
  • Middle Aged
  • Protein Isoforms
  • Receptors, Somatotropin
  • Spinal Fractures

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