GH receptor isoforms and skeletal fragility in acromegaly

Marilda Mormando; Luigi A. Nasto; Antonio Bianchi; Gherardo Mazziotti; Antonella Giampietro; Enrico Pola; Alfredo Pontecorvi; Andrea Giustina; Laura De Marinis Grasso

doi:10.1530/EJE-14-0205

GH receptor isoforms and skeletal fragility in acromegaly

Marilda Mormando, Luigi A. Nasto, Antonio Bianchi, Gherardo Mazziotti, Antonella Giampietro, Enrico Pola, Alfredo Pontecorvi, Andrea Giustina, Laura De Marinis Grasso

University of Brescia

Risultato della ricerca: Contributo in rivista › Articolo in rivista

22 Citazioni (Scopus)

Abstract

Acromegaly is associated with an increased prevalence of vertebral fractures (VFs) in close relationship with GH hypersecretion. Two isoforms of the GH receptor (GHR) have been identified; the two isoforms differ or not by the expression of the protein fragment encoded by exon 3 of the GHR gene. Deletion of the exon 3 may influence the functional properties of the GHR and affect fracture risk in acromegalic patients.

Lingua originale	English
pagine (da-a)	237-245
Numero di pagine	9
Rivista	European Journal of Endocrinology
Volume	171
DOI	https://doi.org/10.1530/EJE-14-0205
Stato di pubblicazione	Pubblicato - 2014

Keywords

Acromegaly
Adult
Aged
Bone Density
Cross-Sectional Studies
Exons
Female
Gene Deletion
Humans
Insulin-Like Growth Factor I
Italy
Male
Middle Aged
Protein Isoforms
Receptors, Somatotropin
Spinal Fractures

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title = "GH receptor isoforms and skeletal fragility in acromegaly",

abstract = "Acromegaly is associated with an increased prevalence of vertebral fractures (VFs) in close relationship with GH hypersecretion. Two isoforms of the GH receptor (GHR) have been identified; the two isoforms differ or not by the expression of the protein fragment encoded by exon 3 of the GHR gene. Deletion of the exon 3 may influence the functional properties of the GHR and affect fracture risk in acromegalic patients.",

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T1 - GH receptor isoforms and skeletal fragility in acromegaly

AU - Mormando, Marilda

AU - Nasto, Luigi A.

AU - Bianchi, Antonio

AU - Mazziotti, Gherardo

AU - Giampietro, Antonella

AU - Pola, Enrico

AU - Pontecorvi, Alfredo

AU - Giustina, Andrea

AU - De Marinis Grasso, Laura

PY - 2014

Y1 - 2014

N2 - Acromegaly is associated with an increased prevalence of vertebral fractures (VFs) in close relationship with GH hypersecretion. Two isoforms of the GH receptor (GHR) have been identified; the two isoforms differ or not by the expression of the protein fragment encoded by exon 3 of the GHR gene. Deletion of the exon 3 may influence the functional properties of the GHR and affect fracture risk in acromegalic patients.

AB - Acromegaly is associated with an increased prevalence of vertebral fractures (VFs) in close relationship with GH hypersecretion. Two isoforms of the GH receptor (GHR) have been identified; the two isoforms differ or not by the expression of the protein fragment encoded by exon 3 of the GHR gene. Deletion of the exon 3 may influence the functional properties of the GHR and affect fracture risk in acromegalic patients.

KW - Acromegaly

KW - Adult

KW - Aged

KW - Bone Density

KW - Cross-Sectional Studies

KW - Exons

KW - Female

KW - Gene Deletion

KW - Humans

KW - Insulin-Like Growth Factor I

KW - Italy

KW - Male

KW - Middle Aged

KW - Protein Isoforms

KW - Receptors, Somatotropin

KW - Spinal Fractures

KW - Acromegaly

KW - Adult

KW - Aged

KW - Bone Density

KW - Cross-Sectional Studies

KW - Exons

KW - Female

KW - Gene Deletion

KW - Humans

KW - Insulin-Like Growth Factor I

KW - Italy

KW - Male

KW - Middle Aged

KW - Protein Isoforms

KW - Receptors, Somatotropin

KW - Spinal Fractures

UR - http://hdl.handle.net/10807/66772

U2 - 10.1530/EJE-14-0205

DO - 10.1530/EJE-14-0205

M3 - Article

SN - 0804-4643

VL - 171

SP - 237

EP - 245

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

ER -

GH receptor isoforms and skeletal fragility in acromegaly

Abstract

Keywords

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