GH receptor isoforms and skeletal fragility in acromegaly

Marilda Mormando, Luigi A. Nasto, Antonio Bianchi, Gherardo Mazziotti, Antonella Giampietro, Enrico Pola, Alfredo Pontecorvi, Andrea Giustina, Laura De Marinis Grasso

Risultato della ricerca: Contributo in rivistaArticolo in rivista

22 Citazioni (Scopus)


Acromegaly is associated with an increased prevalence of vertebral fractures (VFs) in close relationship with GH hypersecretion. Two isoforms of the GH receptor (GHR) have been identified; the two isoforms differ or not by the expression of the protein fragment encoded by exon 3 of the GHR gene. Deletion of the exon 3 may influence the functional properties of the GHR and affect fracture risk in acromegalic patients.
Lingua originaleEnglish
pagine (da-a)237-245
Numero di pagine9
RivistaEuropean Journal of Endocrinology
Stato di pubblicazionePubblicato - 2014


  • Acromegaly
  • Adult
  • Aged
  • Bone Density
  • Cross-Sectional Studies
  • Exons
  • Female
  • Gene Deletion
  • Humans
  • Insulin-Like Growth Factor I
  • Italy
  • Male
  • Middle Aged
  • Protein Isoforms
  • Receptors, Somatotropin
  • Spinal Fractures


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