Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients. In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) following FLC treatment in order to investigate the adaptive cellular responses to drug stress.
- Antifungal Agents
- Cryptococcus neoformans
- Gene Expression Profiling
- Gene Expression Regulation, Fungal
- Stress, Physiological