Genetic variation at the ApoB 3' HVR, D2S44, and D7S21 loci in the Ewondo ethnic group of Cameroon

Vincenzo Lorenzo Pascali, Ernesto D'Aloja, Marina Dobosz, G. Destro Bisol, S. Presciuttini, G. Spedini

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

A sample of the Ewondo population (a Bantu-speaking group of Southern Cameroon) was analyzed for the polymorphism at three tandem repeated DNA loci (ApoB 3' HVR, D2S44, and D7S21). We observed a greater number of ApoB 3' HVR alleles (17) and a significantly higher estimated heterozygosity (.879 +/- .011) than in previously surveyed populations, with the exception of U.S. Blacks. The higher genetic variability of Ewondo and U.S. Blacks was also shown by the ApoB 3' HVR allele-frequency spectra. A method for measuring population distances, based on cumulative fragment-size distribution, is described. Interpopulation comparisons for ApoB 3' HVR were carried out by this method and were compared with those obtained by a genetic distance measurement. The two sets of results showed a consistent pattern of population differentiation: the Ewondos and the U.S. Blacks clustered together and were well apart from both a Caucasian cluster (Swedes, U.S. Whites, Italians, and Germans) and other well-defined populations (Sikhs of India and Pehuence Indians of Chile). Profile distances were then computed from D2S44 and D7S21 bined data. This analysis indicated a genetic affinity between Ewondos, U.S. Blacks, and Afro-Caribbean Blacks and outlined the genetic diversity between Ewondos, Caucasians, and Asian Indians.
Lingua originaleEnglish
pagine (da-a)168-174
Numero di pagine7
RivistaAmerican Journal of Human Genetics
Volume55
Stato di pubblicazionePubblicato - 1994

Keywords

  • Gene Frequency
  • Polymorphism, Restriction Fragment Length
  • Repetitive Sequences, Nucleic Acid/genetics

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