Genetic variants associated with physical performance and anthropometry in old age: A genome-wide association study in the ilSIRENTE cohort

Emanuele Marzetti, Francesco Landi, Anna Picca, Riccardo Calvani, David Heckerman, Bryan J. Traynor, Dena Hernandez, Michael Nalls, Sampath Arepali, Luigi Ferrucci

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

Unraveling the complexity of aging is crucial for understanding its mechanisms and its role as a risk factor for most chronic conditions. Advancements marked by genome-wide association studies (GWASs) have sparked interest in gene cataloguing in the context of aging and age-related conditions. Here, we used GWAS to explore whether single nucleotide polymorphisms (SNPs) were associated with functional and anthropometric parameters in a cohort of old community-dwellers enrolled in the ilSIRENTE study. Analyses were carried out in men and women aged 80+ years enrolled in the ilSIRENTE study (n = 286) and replicated in the inCHIANTI study (n = 1055). Genotyping was accomplished on Infinium Human610-QUAD version 1. In the ilSIRENTE population, genetic variants in ZNF295 and C2CD2 (rs928874 and rs1788355) on chromosome 21q22.3, were significantly associated with the 4-meter gait speed (rs928874, p = 5.61 × 10-8; rs1788355, p = 5.73 × 10-8). This association was not replicated in the inCHIANTI population. Our findings suggest that specific SNPs may be associated with a key measure of physical performance in older adults. GWASs using larger samples are needed to confirm these preliminary results to enhance our comprehension of complex age-associated phenomena.
Lingua originaleEnglish
pagine (da-a)15879-15888
Numero di pagine10
RivistaScientific Reports
Volume7
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Multidisciplinary

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