TY - JOUR
T1 - Genetic dynamics in untreated CLL patients with either stable or progressive disease: A longitudinal study
AU - Ramassone, A.
AU - D'Argenio, A.
AU - Veronese, A.
AU - Basti, A.
AU - Soliman, S. H. A.
AU - Volinia, S.
AU - Bassi, C.
AU - Pagotto, S.
AU - Ferracin, M.
AU - Lupini, L.
AU - Saccenti, E.
AU - Balatti, V.
AU - Pepe, F.
AU - Rassenti, L. Z.
AU - Innocenti, I.
AU - Autore, F.
AU - Marzetti, L.
AU - Mariani-Costantini, R.
AU - Kipps, T. J.
AU - Negrini, M.
AU - Laurenti, Luca
AU - Visone, R.
PY - 2019
Y1 - 2019
N2 - Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggressive disease shift. We found that clonal evolution occurs in all CLL patients, irrespective of the clinical outcome, but is faster during disease progression. In particular, changes in the frequency of nucleotide variants (NVs) in specific CLL-related genes may represent an indicator of poor clinical outcome.
AB - Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggressive disease shift. We found that clonal evolution occurs in all CLL patients, irrespective of the clinical outcome, but is faster during disease progression. In particular, changes in the frequency of nucleotide variants (NVs) in specific CLL-related genes may represent an indicator of poor clinical outcome.
KW - Chronic lymphocytic leukemia
KW - Clonal evolution
KW - Copy number variation
KW - Nucleotide variation
KW - Chronic lymphocytic leukemia
KW - Clonal evolution
KW - Copy number variation
KW - Nucleotide variation
UR - https://publicatt.unicatt.it/handle/10807/144459
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85075309544&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85075309544&origin=inward
U2 - 10.1186/s13045-019-0802-x
DO - 10.1186/s13045-019-0802-x
M3 - Article
SN - 1756-8722
VL - 12
SP - N/A-N/A
JO - Journal of Hematology and Oncology
JF - Journal of Hematology and Oncology
IS - 1
ER -