Genetic dynamics in untreated CLL patients with either stable or progressive disease: A longitudinal study

Luca Laurenti, Francesca Lassandro Pepe, Idanna Innocenti, Francesco Autore, Alice Ramassone, Andrea D'Argenio, Angelo Veronese, Alessio Basti, Shimaa Hassan Abdelaziz Soliman, Stefano Volinia, Cristian Bassi, Sara Pagotto, Manuela Ferracin, Laura Lupini, Elena Saccenti, Veronica Balatti, Felice Pepe, Laura Z. Rassenti, Laura Marzetti, Renato Mariani-CostantiniThomas J. Kipps, Massimo Negrini, Rosa Visone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

2 Citazioni (Scopus)

Abstract

Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggressive disease shift. We found that clonal evolution occurs in all CLL patients, irrespective of the clinical outcome, but is faster during disease progression. In particular, changes in the frequency of nucleotide variants (NVs) in specific CLL-related genes may represent an indicator of poor clinical outcome.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJOURNAL OF HEMATOLOGY & ONCOLOGY
Volume12
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Chronic lymphocytic leukemia
  • Clonal evolution
  • Copy number variation
  • Nucleotide variation

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