Abstract
The molecular pathogenesis of poorly differentiated endocrine carcinomas of the gastrointestinal tract (GI PDECs) remains unclear. It has been suggested that these lesions either originate from multipotent stem cells that also can serve as the origin of nonendocrine adenocarcinomas or arise due to the dedifferentiation of well-differentiated endocrine carcinomas (WDECs).
| Lingua originale | Inglese |
|---|---|
| pagine (da-a) | 1273-1282 |
| Numero di pagine | 10 |
| Rivista | Cancer |
| Volume | 98 |
| Numero di pubblicazione | 6 |
| DOI | |
| Stato di pubblicazione | Pubblicato - 2003 |
All Science Journal Classification (ASJC) codes
- Oncologia
- Ricerca sul Cancro
Keywords
- 80 and over
- Acid Anhydride Hydrolases
- Adult
- Aged
- Colorectal Neoplasms
- Cyclin-Dependent Kinase Inhibitor p16
- Endocrine Gland Neoplasms
- Female
- Gastrointestinal Neoplasms
- Humans
- Immunohistochemistry
- Loss of Heterozygosity
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 1
- Neoplasm Proteins
- Retinoblastoma Protein
- Tumor Suppressor Protein p53
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